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33 Cards in this Set

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Viral Acute Bronchitis
Agents?
Rhinovirus, Coronaviruses, Adenoviruses, Influenza viruses
Respiratory Syncytial Virus
Agent?
Vaccine?
Paramyxovirus family
(mumps, measles, RSV)
Vaccine = NO
RSV
Disease?
Virulence Factors?
75% Bronchiolitis by RSV
Leading cause of serious
(pneumonia in infants/child)
Protein G, Protein F
Protein G
Attachment
Protein F
Fusion of virus surface with epithelial Cells
Also causes cell culture to fuse together (syncytia)
RSV
Mode of Action?
Sloughing resp. epith.
Inflammatory resp = cause bronchiolitis.
Pneumonia = bronchiolar and alveolar inflammation or 2nd infection
Hantavirus Pulmonary Syndrome
Agent?
Sin Nombre Virus
Bunyavirus Family
Infected Mice Feces
Influenza Virus Infection
Agent?
Influenze A Virus
Orthomyxovirus Family
(ssRNA, envelope, helical nucleocapsid)
Antigenic Shifts!
Composition of Influenza Virus
Hemagglutinin,
Neuraminidase,
Lipid envelope,
- RNA, Matrix protein
Hemagglutinin (H)
Bind to host cell and fusing of viral envelope
Neuraminidase (N)
Release Virus FROM cell surface (budding)
Influenze Prevention
Vaccines = 80-90% eff.
Amantidine, Rimatadine (A)
Neuraminidase (A) (B)
SARS-associated coronavirus
Guangdong Province outbreak.
Fever > 38 C.
SARS CoV (EM, PCR, Serology)
Pertussis
Agent?
Vaccine?
Bordetella pertussis
-, rod
Vaccine = YES
Acellular
Pertussis
Pathogenesis?
Feature?
A-B exotoxin,
Endotoxin (LPS)
Cytotoxin
Paroxysmal Cough, Fever
Pertussis
Mode of Action?
A-B Toxin
A activates ADP ribosylationg of G protein
= Inc cAMP, death epith cells
Bacterial pneumonia
Agents?
Pneumococcal pneumoniae
Klebsiella pnemonia
Myoplasmal pneumonia
Hemophilus influenzae
Moraxella catarrhalis
Staph aureus
Pneumococcal Pneumonia
Treatment?
Capsular Vaccine
Conjugate vaccine (infants)
Penicillin, erythromycin
Klebsiella Pneumonia
Treatment?
No vaccine
Cephalosporin, aminoglycoside
Mycoplasmal Pneumonia
Treatment?
No vaccine
Tetracycline, erythromycin
Pneumonoccal pneumonia
Agent?
Strep pneumoniae
Pneumoncoccal pneumoniae
Virulence Factor?
Capsule
Klebsiella pneumonia
Virulence Factor?
Capsule (mucoid colonies)
R Plasmids
Klebsiella pneumonia
Complications?
Lung Abscesses
Bacterimia
PERMANENT damage to lungs
Very slimy when grown (biofilm)
Mycoplasmal pneumonia
Virulence Factor?
No Cell wall
Walking pneumonia
Legionnaire's Disease
Agent?
Legionella pneumophila
-, gamma proteobacteria
Legionnaire's Disease
Pathogenesis
Due to High Infecting Dose
Multiplies within Pagocytes
Necrosis of cells lining alveoli, microabscesses
Legionnaire's Disease
Treatment?
Erythromycin, Rifampin
Tuberculosis
Agent?
Mycobacterium tuberculosis
Chronic
Tuberculosis
Pathogenesis?
Chronic, Slow Generation time
Multi-drug resistant
Granuloma formation
Tuberculosis
Screening?
Tuberculin Test (Mantoux)
Antigenic Sensitivity
Tuberculosis
Treatment?
BCG Vaccine
Isoniazid, Rifampin
Pseudomonas Respiratory infections r/Cystic Fibrosis
Predisposition to
Pseudomonas aeruginosa,
S aureus, H influenzae