Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
20 Cards in this Set
- Front
- Back
|
lipidopeptide?
|
daptomycin
|
|
|
mech?
|
lipid tail inserts into membrane and binds calcium. Then daptomycin aggregates and forms pore. membrane potential is lost.
|
|
|
bacter.....what?
|
cidal against gram pos
|
|
|
what kind of killing?
works against what that is exciting? approved for? |
concentration dependent
biofilms MRSa, vre, and vrsa |
|
|
Polymyxins?
works against what what's special about it? |
polymyxin b and e
gram neg (drug of last resort against g negs) |
|
|
Metronidazole
|
flagyl
anaerobes and fac anaerobes nitro group reduced to a free radical leads to damage. very lipid soluble so can get into cns well. number 1 drug to treat metronidazole. causes metallic taste, headache, disulfuram reaction...(inhib of alcohol dehydrogenase) |
|
|
spectinomycin
|
only treats n gonorrhea
no activity against t pallidum |
|
|
which are only g +
|
vanco, telavancin, bacitracin, quinupritin/dalfopristin, liezolid, daptomycin
|
|
|
only g neg
|
aztreonam, polymyxin b, polymyxin E (colistin)
|
|
|
Tuberculosis
|
1/3 of world pop with tb
16000 cases /yr in US |
|
|
Isoniazid
moa? |
most important
activation of catalas and peroxidase inhibs mycolic acid sythesis resistance from loss of catalase/peroxidase gene |
|
|
isoniazid has something to do with what enzyme ?
|
kat g (catalase peroxidase)
converts isnzd into active form inside m tb. orally administered, metabolism by n acetylation, can have slow acetylators but do effect on efficacy.....but slow do have higher periph neuropathy |
|
|
how does periph neurop occur?
|
b6 (pyridoxine) depletion
|
|
|
other adverse?
|
hepatitis;
|
|
|
rifampin
|
has 10000 greater affinity for bacterial dna dep rna pol
|
|
|
adverse?
|
turns secretion bright orange.
|
|
|
ethambutol adverse
|
dose related retrobulbar neuritis (ocular tox)
decrease in visual acuity and visual fields, and red/green differentiation |
|
|
pyrazinamide
|
analog of nicotinamide;
mech not known; hepatic tox |
|
|
streptomycin
|
ototoxic (vestibular)
nephrotoxic not absorbed orally |
|
|
leprosy drugs?
|
dapsone (similar to sulfonamides)
rifampin clofazimine |
