Lipid Regulating Drugs Pharm 2015

Front 1

Lipid Regulating Drug Classes

Back 1

-HMGCoA Reductase Inhibitors (statins)
-Bile Acid Sequestants (resins)
-Ezetimibe
-Nicotinic Acis
-Fibrates
-Fish Oils

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HMGCoA Reductase Inhibitors
-Drug Names
-MOA
-SE
-CI
-Combinations

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-Drug Names, Atrovastatin (long half life) Simvastatin (short half life
-MOA - 1. decreaes choloesterol production in the liver
2. increaase removal of LDL by liver from circulation
-SE, well tolerate, rised liver transminases, myalgia or rhabdomyolysis
-CI: metabolised by CYP450 ensyme, can lead to interacitons ith other drugs metabolised also with this enzyme
-Combinations: statins and resin

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Bile Acid Sequestrants 'Resins'
-Drug Names
-MOA
-SE
-CI
-Combinations

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-Drug Names, 'resins'
-MOA, 'resins (+ve) bind to bile acids (-ve) in the intestinal lumen and prevent the reabsorption
-SE can increase TG, can cuase some GIT upset, constipation
-CI, because of charge, other drugs with charge can bind
-Combinations, resin and statin

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Ezetimibe
-MOA
-SE
-Combinations

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-MOA, selectively inhibits absoprtion of cholesterol from the intestine by binding to cholesterol molecule transporters
-SE, long last effect, can circulate many times in intestine
-Combinations, ezetimibe and statin

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Nicotinic Acid
-MOA
-SE
-CI

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-MOA, poorly understood, liver produces less triglyceride (main effect)
-SE, flushing, GI upset/bleeding, elevated uric acid and blood glucose
-CI, GI ulcers, gout, diabetes

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Fibrates
-Drug Names
-MOA
-SE
-CI
-Combinations

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-Drug Names, Gemfibrozil
-MOA, activate PPARa ( found in liver and adipose tissue), increase lipoprotien lipase activity
-SE, risk of myopathy
-CI, statins - inhibit absorption

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Fish Oil
-Drug Names
-MOA
-SE
-CI
-Combinations

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-Drug Names, omega 3 marine TG's
-MOA, poly-saturated FA's, decrease plasma TG's but increase cholesterol, may have anti-coagulant and anti-inflammatory effect
-SE, GI upset