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6 Cards in this Set
- Front
- Back
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HMGCoA Reductase Inhibitors (statins)
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Atorvastatin (long half life)
Simvastatin (short half life) 1. Decrease cholesterol production in the liver. 2. Increase removal of LDL by liver from circulation. |
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Bile Acid Sequestrants “Resins”
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‘resins’
Resins (+ve charge) bind to bile acids (-ve charge) in the intestinal lumen and prevent their reabsorption. |
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Ezetimibe
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Selectively inhibits absorption of cholesterol from the intestine by binding to cholesterol molecule transporters.
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Nicotinic Acid
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Poorly understood – liver produces less triglycerides (main effect)
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Fibrates
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Gemfibrozil
- activate PPARa (found in liver and adipose tissue) - increase lipoprotein lipase activity, decreasing levels of TG. |
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Fish oils
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Omega 3 marine TG’s
- polyunsaturated FA’s - decrease plasma TG’s but increase cholesterol - may have anti-coagulant & anti-inflammatory effect. |
