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19 Cards in this Set
- Front
- Back
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inhibits HMG co-reductase by competitively inhibiting mevalonate
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statins
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most effective in increasing HDL
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niacin
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flushing (decreased by aspirin), hyperglycemia, hyperuricemia (gout), hepatitis
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niacin
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inhibits lipolysis in adipose tissue & reduces VLDL secretion into circulation (bc no FFA from fat to make it)
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niacin
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what class of drug: cholestyramine, colestipol
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bile acid resin
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prevents intestinal reabsorption of bile acids, forcing liver to use more cholesterol to make more
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bile acid resin
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side effect: increases TG's
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bile acid recins
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most powerful in lowering LDL
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statins
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side effects: taste bad, GI discomfort, decreased absorption of fat soluble vitamins, gallsotones
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bile acid resins
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Slightly increases HDL
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bile acid resins
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side effects: myositis, increase LFT's, dyspepsia, GALLSTONES,
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fibrates
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what class of drugs: gemfibrozil, clofibrate, bezafibrate,
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fibrates
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Mechanism: suppress cholesterol 7 alpha hydroxylase, increasing cholesterol secretion into bile & upregulates LPL to increase TG clearance
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fibrates
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most powerful in reducing TG's
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fibrates
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ONLY has effect on lowering LDL (no effect on HDl, or TG)
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cholesterol absorption blockers (ezetimibe)
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what is ezetimibe?
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cholesterol absorption blocker
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what drug prevents cholesterol reabsorption at small intesting brush border?
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ezetimibe
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what drug causes rare increase in LFT's??
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ezetimibe
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what drugs are expensive, cause reversible increase in LFT's, myositis & myopathy
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statins
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