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7 Cards in this Set
- Front
- Back
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What are the pharmacokinetics of fluoroquinolones?
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Bactericidal antibiotics
Concentration-dependent killing effect The higher peak concentration results in more rapid and complete killing of susceptible organisms |
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Mechanism of action of fluoroquinolones?
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Strong inhibitors of DNA gyrase and topoisomerase IV.
These enzymes are critical to the process of supercoiling DNA. DNA can't replicate |
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Mechanism of resistance to fluoroquinolones?
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1. Chromosomal mutations
2. alterations in their ability to permeate the bacterial cell wall. |
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Clinical Uses of Fluoroquinolones?
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UTI
STD Skin and soft tissue infections GI infections Osteomyelitis Resp tract infections |
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Which Fluoroquinolone do you use for hospital acquired infection and why?
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ciprofloxacin (Cipro) because it has the best activity against Proteus aeruginosa
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Which Fluoroquinolone would you use for community-acquired infection and why?
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Newer FQ
Levofloxacin (Levaquin) Moxifloxacin Greatest activity against S. pneumoniae |
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Which Fluoroquinolone is recommended for meningococcal prophylaxis?
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Ciprofloxacin (Cipro)
Single 500 mg PO dose |
