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12 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Chronic Myeloproliferative Disorder
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t9;22
(fusion of BCR on C22 w/ regions of ABL on C9) |
Blood smear: PMS in various stages of maturation; maybe increased baso/eos; not much dysplasia
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Polycythemia Vera
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JAK2 (non-specific), no t9;22
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Blood smear: increase in red cell mass and hct; normochromic, normocytic RBCS, maybe w/ neutrophilia/basophilia, thrombocytosis
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Primary Myelofibrosis
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JAK2 (non-specific), no t9;22
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BS:Fibrotic stage: Leukoerythroblastosis and tear drop RBC
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Essential Thrombocythemia
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JAK 2 in 40-50%
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Bone marrow biopsy shows increased number of megakaryocytes
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Cutaneous Mastocytosis
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Mast cells + for CD117
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Refractory anemia with isolated _____
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5q deletion
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Greater than 5% blasts in blood; hypercellular BM; dysplasia is uncommon
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Myeloid Ags
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CD13, 33, 117
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Immature markers on blasts
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CD34, HLA-DR
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AML with recurrent genetic Abnormalities: disruption of normal function of core binding factor (CBF) by chimeric protein
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t(8;22)(q22;22)
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When detected, even cases wih <20% blasts should be considered AML
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AML; fusion of CBFbeta and MYH11 which disrupts core binding factor
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inversion 16(p13;q22)
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Acute Promyelocytic Leukemia
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t(15;17)(q22;q12)
PML and RARA genes involved CD13, CD22 pos, CD34 neg (more mature cell) |
Increased PROmyelocytes:
medical emergency... ass. with DIC |
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AML with therapy related leukemia after treatment with DNA topoisomerase II inhib
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11q23 (MLL chromosome)
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gingival hypertrophy~!
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