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17 Cards in this Set

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CML:
: chromosome
: blood work
: other labs
: blast crisis
: arthritis?
: philidelphia. t(9:22). bcr-abl
: neutrophilia (hyperseg), thrombocytosis. hbg normal or inc. basophiphilia, eosinophilia
: dec LAP and increased B12
: some lymphos. 3-4yrs after diag. interferon and imantinib
: hyperuricemia = arthritis
PV
: symptoms/signs
: blood work
: molecular marker?
: HA, dizziness, vertigo, CNS. angina. spleno. PRURITIS. budd-chiari=thrombosis, thrombocytosis
: no anemia, Fe deficiency. high b12. low EPO. inc. megakary. macrocytic RBC
: JAK 2?
ET
: symptoms/signs
: R.O secondary cuases
: jak 2
: also leukoctosis and marrow fibrosi. no spleno
: CML, iron eficiency, infection, PV, myelofibrosis
MF
: signssymptoms
: leuko, thrombocytosis, anemia (spenic sequest) Huge spleen from platlet derived GF-->fibrosis of BM. Clone goes to spleen and liver.
Myelodisplastic Syndromes

Myeloproliferative cell character
: things MP in common
: dysplastic, ineffective blood. not myeloproliferative.
: macrocytic anemia, neutro and thrombo penia.
: all have mature cell types
: excessive, PMN, basophils, plats
Blast phase:
: cells don't mature. additional mutations. neutropenia, basophilia, thrombocytopenia.
: go to death. BMT won't help
: DIC? lots of blasts, no mature cells
: BMT only help
gleevac;
: remission rate
: blast crisis
: 90% remission rate.
: can happen very unexpectedly. no clones-->blast crisis
Acute leukemia:
Clinical findings
: malaise, fever, bleeding. hepatospleno. CNS involve.
: pancyto of mature cells
ALL
: age
: Sanctuary sites
: signs/symptoms
: most common of children: more common that CML overall
: yes, testes and CNS years later
: rectal lesions common, look like Aplastic anemia. gingival hypertorphy. skin tumors. hypoK
ALL Classification:
L1:
L2
L3
: childhood. Cd10+
: adulthood. 30% have Phil Chr
: adolescent, aggressive. Burkitt's. c-myc. t(8:14), (2:8), (8:22). huge proliferation.
ALL immunologic classes
null pre-pre-B
pre-B
B
T
two most frequent markers
: CD10+ CALLA, CD19
: Cytoplasmic IgM
: surface membrane Ig
: CD 7,2, 10 bospitive
: CALLA and TdT.
: bad untreated prognosis
AML
: M1
: M2
: M3
: no differentiation. often with myelodysplasia. no granules.
: With differentiation
: Promyelocytic. t(15:17) RAR. auer rods
AML
: M4
: M5
: M6
: m7
: Myelomonocytic
: monocytic, look like mature moncytes
: erythroid
: megakaryocytic
AML
cytochemical stains:
: + peroxidase and sudan black B positive (blast cells)
bad chromosome indications:
: loss of 5 or 7 arm. t(9:22)
ALL
: type of cell
: markers
: earliest B cell in marrow--> through all stages possible develop ALL. pre-b cell problem
: CD10. TdT. helps variablize Ig genes. no granules
Treatment ALL
corticosteroids, vinca alkyls
anthracycline
CNS prophylaxis