• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/18

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

18 Cards in this Set

  • Front
  • Back
The growth of leukemic cells in the bone marrow give rise to the clinical triad of _____, _______ and _______.
anemia (from lack of RBC production), infection (lack of normal WBCs), and bleeding/bruising (lack of platelets)
This is a clonal malignancy of lymphoid precursor cells (lymphoblast) in the bone marrow.
A. Acute lymphoblastic leukemia (ALL)
B. Acute myelogenous leukemia(AML)
C. Chronic lymphocytic leukemia (CLL)
D. Chronic myelogenous leukemia (CML)
E. Acute promyelocytic leukemia (APL)
A. Acute lymphoblastic leukemia
This is a proliferaiton of immature myeloid cells derived from malignant transformation of a myeloid precursor cell.
A. Acute lymphoblastic leukemia (ALL)
B. Acute myelogenous leukemia(AML)
C. Chronic lymphocytic leukemia (CLL)
D. Chronic myelogenous leukemia (CML)
E. Acute promyelocytic leukemia (APL)
B. Acute myelogenous leukemia(AML)
and
E. Acute promyelocytic leukemia (APL)
malignant clonal disorder of relatively mature, indolent B lymphocytes (95%) or T lymphocytes (5%) which multiply SLOWLY.
A. Acute lymphoblastic leukemia (ALL)
B. Acute myelogenous leukemia(AML)
C. Chronic lymphocytic leukemia (CLL)
D. Chronic myelogenous leukemia (CML)
E. Acute promyelocytic leukemia (APL)
C. Chronic lymphocytic leukemia (CLL)
malignancy of the myeloid stem cell, which results in the production of excess myeloid cells.
A. Acute lymphoblastic leukemia (ALL)
B. Acute myelogenous leukemia(AML)
C. Chronic lymphocytic leukemia (CLL)
D. Chronic myelogenous leukemia (CML)
E. Acute promyelocytic leukemia (APL)
D. Chronic myelogenous leukemia (CML)
If Auer rods are present upon histological examination, you've got:
A. Acute lymphoblastic leukemia (ALL)
B. Acute myelogenous leukemia(AML)
C. Chronic lymphocytic leukemia (CLL)
D. Chronic myelogenous leukemia (CML)
E. Acute promyelocytic leukemia (APL)
E. Acute promyelocytic leukemia (APL)

a proliferaiton of immature myeloid cells derived from malignant transformation of a myeloid precursor cell, a subset of AML
In this condition, most people will have some kind of cytogenetic abnormality (karyotype) like t(8;21) or trisomy 8.

A. Acute lymphoblastic leukemia (ALL)
B. Acute myelogenous leukemia(AML)
C. Chronic lymphocytic leukemia (CLL)
D. Chronic myelogenous leukemia (CML)
E. Acute promyelocytic leukemia (APL)
B. Acute myelogenous leukemia(AML)
Which acute leukemia is primarily a disorder of children and which is primarily a disorder of adults?
A. Acute lymphoblastic leukemia (ALL)= children

B. Acute myelogenous leukemia(AML) = adults
Which leukemia condition(s) will have the following cytochemistry:
A. positive for myeloperoxidase
B. positive for terminal deoxytransferase (TdT)
MYELOPEROXIDASE + :
B. Acute myelogenous leukemia(AML)
E. Acute promyelocytic leukemia (APL)

TdT + :
A. Acute lymphoblastic leukemia (ALL)
CD2 and CD3 are characteristic of [ B / T / stem cell antigen ] cells; CD10, CD19, CD20 are characteristic of [ B/ T / stem cell antigen] cells ; CD34 is characteristic of [ B/ T / stem cell antigen].
CD2 and CD3 (characteristic of T cells)
CD10, CD19, CD20 ( characteristic of B cells)
CD34 (stem cell antigen, found in all acute leuks)
What leukemia is the following immunophenotype found on?
CD2 and CD3 (characteristic of T cells)
CD10, CD19, CD20 ( characteristic of B cells)
CD34 (stem cell antigen, found in all acute leuks)
Acute lymphoblastic leukemia
(ALL)
What leukemia is the following immunophenotype found on?

CD13 and CD33 (characteristic of myeloid cells)
CD34 (stem cell antigen, found in all acute leuks)
Acute myeloid leukemia
(AML)
Which condition has the following clinical findings and symptoms?
* anemia, leukopenia, thrombocytopenia
* gingival and cutaneous involvement

A. Acute lymphoblastic leukemia (ALL)
B. Acute myelogenous leukemia(AML)
C. Chronic lymphocytic leukemia (CLL)
D. Chronic myelogenous leukemia (CML)
E. Acute promyelocytic leukemia (APL)
F. Multiple myeloma (MM)
B. Acute myelogenous leukemia(AML)
What is the common genetic change seen in Acute promyelocytic leukemia (APL)?
A. t(8;21) or trisomy 8
B. t (15; 17)
C. trisomy 12
D. t(9;22)
B. t (15; 17)
What is the condition associated with each?
A. t(8;21) or trisomy 8
B. t (15; 17)
C. trisomy 12
D. t(9;22)
A. t(8;21) or trisomy 8 : Acute myeloid leukemia (AML).
B. t (15; 17): AML subset: Acute promyelocytic leukemia (APML) breakpoint is the retinoic acid receptor gene and thus the treatment of choice for APL is not standard therapy as for AML but instead is all-trans retinoci acid in combo with chemo
C. trisomy 12: Chronic lymphocytic leukemia (CLL)
D. t(9;22)
BCR-ABL fusion gene(tyrosine kinase initiates the transformation of the stem cell to a leukemic cell)
Philadelphia chromosome
What general age group does each hit?
A. Acute lymphoblastic leukemia (ALL)
B. Acute myelogenous leukemia(AML)
C. Chronic lymphocytic leukemia (CLL)
D. Chronic myelogenous leukemia (CML)
E. Acute promyelocytic leukemia (APL)
F. Multiple Myeloma (MM)
A. Acute lymphoblastic leukemia (ALL) = children
B. Acute myelogenous leukemia(AML) = adults
C. Chronic lymphocytic leukemia (CLL) = disease of older (middle aged ane elderly) adults - rare before 40s.
D. Chronic myelogenous leukemia (CML) = young and middle aged adults
F. Multiple Myeloma (MM) = older adults
Chronic lymphocytic leukemia is also called __________________.
Small lymphocytic lymphoma.

usually only discovered during a routine peripheral blood examination because systemic symptoms are much less common than in other types of chornic leukemias.
* In some patients: History of weakness, fatigue, anorexia, weight loss, generalized nontender adenopathy and splenomegaly.

absolute lymphocytosis with small lymphocytes with mature cytologic features resembling those normally present in peripheral blood. BUT these are more fragile and disintegrate during smear prep forming " smudge cells ".
Which condition does this describe: absolute lymphocytosis with small lymphocytes with mature cytologic features resembling those normally present in peripheral blood. BUT these are more fragile and disintegrate during smear prep forming " smudge cells ".
Chronic lymphocytic leukemia

aka Small lymphocytic lymphoma