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12 Cards in this Set
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- Back
- 3rd side (hint)
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CHRONIC MYELOID LYMPHOMA- pathogen and clinical manifest
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Pathogenesis:
onset: 40 to 50 years old Philadelphia chromasome; chromosome 9 and 22* increases proliferation, decreases apoptosis bcr/abl clinical: high granulocyte count splenomegaly |
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CHRONIC MYELOID LYMPHOMA- prog +tx
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prog:
does not respond well to chemo treatment survival 2 years.... very poor tx: imatinib(target bcr/abl) allogeneic bone marrow transplant |
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ACUTE MYELOID LEUKEMIA pathogenesis and clinical mani.
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patho:
median age 64y/o bombe marrow aspirate contains more than 20 PERCENT BLASTS different stem cells diff. subtypes of AML ex. m 1-3 neutrophil.... m5 monocyte, m6 rbc, m7 megakaryocytes(plts) m2 most common ACUTE GRANULOCYTIC LEUKEMIA PRESENT: bone pain, anemia, thrombocytopenia, immune suppression (skin, GU, GI, RT) |
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ACUTE MYELOID LEUKEMIA- prog n tx
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PROGNOSIS: 30% adukts; 50% children *APL exception.... ritonoic acid tx and 70% survival* using targeted tx based on cytogenic profile idarubicin+ara-c +etoposide.....ICE protocol daunorubicin+araC+6thioguanine. ... DAT protocols remission induction (CR attempted) and consolidation/post remission(get rid of undetected Leukemis cells) |
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CHRONIC LYMPHOID LEUKEMIA- path n clin. man
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onset:65 to 70
usually asymptomatic may have: fatigue, weight loss, anorexia increased for certain infection: b cells don't produce ab normally lymphadenopathy/splenomegaly decrease: rbc, plts |
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CHRONIC MYELOGENOUS LEUKEMIA-prog+mani
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igV: w/ 24y survival, w/o: less than 8 years
short lelomere length n tp53 dysfx: poor |
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ACUTE LYMPHOBLASTIC LEUKEMIA/ LYMPHOMA
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CHILDREN: 3 TO 7 Y/O :(; MIDDLE AGE
atleast 20% must be lymphoblastic for dx accumulate in large numbers: blood and BM Bone pain, bruising, fever, infection CHILDREN LYMOHADENOPATHY SPLENOMEGALY, LIVER CNS |
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ACUTE LYMPHOBLASTIC LEUKEMIA/LYMPHOMA- prognosis+tx
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5 year survival: 85% children ; 30 to 50% in adults
chemotherapy: remission and post remission w or wo stem cell transplant monab |
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HAIRY CELL LEUKEMIA- path+clinman
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rare, chronic
highly tx 55y/o, men more common lower rbc, pkts, granulocyte splenomegaly HCL inblood |
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HAIRY CELL LEUKEMIA prog+tx
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tx when patient becomes symptomatic
CR 80% |
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PLASMA CELL MYELOMA (MULTIPLE MYELOMA)- patho +clinman
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onset: 65y/o
belong to a sing clone, excess ab produced are identical monab accumulate in blood stream: SERUM PROTEIN ELECTROPHORESIS Light chain fragments: BENCE JONES PROTEIN (can accumulate in kidneys; kidney damage) malignant plasma cells accumulate in bone.... bone lesions. hypercalcemia monab peak, Bence Jones proteins (urine), hypercalcemia, bone lesions. dx: BM biopsy |
honeycomb bones
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PLASMA CELL MYELOMA (MULTIPLE MYELOMA)-prog+tx
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60%
high dose chemo allogeneic BMT LOCALIZED RADIATION narcotic and non narcotic helps with bone pain |
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