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19 Cards in this Set
- Front
- Back
leukemia
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-cancer of the blood or bone marrow
-abnormal proliferation of leukocytes |
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lymphoid neoplasm
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t and b cells tumors
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myeloid neoplasm
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transformed hemopoietic stem cells
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histiocytoses
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acc. of histocytes in tissues
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etiology
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radiation
chemo translocation genetic disorders |
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leukemia's
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bone marrow
increase in tumor cells in peripheral blood |
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lymphomas
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proliferation of tissue masses
lymph nodes spleen hodgkin lymphoma and non |
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acute leukemias
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-blasts predominant
-short and drastic course -AML-myloids ALL-lymphoblasts (pre t and b) |
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ALL
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acute lymphoblastic leukemia
-children -neoplastic transformation of stem cells -lymphoblasts in BM -suppression of normal hemopoiesis B=80 T=20 |
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AML
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acute myeloid leukemia
-adults -myeloblasts: monoblasts, eosinoblasts, megakarloblasts, proerythroblasts, basophiloblasts -auer rods malignancy |
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myloblasts
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unipotent stem cell- differentiate into granular series
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auer rods
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clumps of asurophillic granular material that form elongated needles
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chronic leukemias
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-more mature cells
-middle age -longer, less devastating course |
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CLL
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chronic lymphocytic leukemia
-adults in west -monoclonal lymphoproliferative disorder -lymphocytosis -lymphadenopathy splenomagaly -smudge cells -uncontrolled proliferation of myeloid cells |
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CML
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chronic myeloid leukemia
-sustained granulocytosis with immature cells, -bone marrow pathology |
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CML symptoms
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-non specific
-hypermetabolism (high cell turnover) -splenomegaly |
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CML course
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-chronic phase (3-4)
-accelerated phase -blast crisis/ myeloid or lymphoid (less 1) |
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CML therapy
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chemo
BMT |
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philadelphia chromosome
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hybrid chromo. with translocation bw long arm of 9 and long arm of 22
-may be present in granulocyte, RBC, platelet precursors |