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19 Cards in this Set

  • Front
  • Back
leukemia
-cancer of the blood or bone marrow
-abnormal proliferation of leukocytes
lymphoid neoplasm
t and b cells tumors
myeloid neoplasm
transformed hemopoietic stem cells
histiocytoses
acc. of histocytes in tissues
etiology
radiation
chemo
translocation
genetic disorders
leukemia's
bone marrow
increase in tumor cells in peripheral blood
lymphomas
proliferation of tissue masses
lymph nodes
spleen
hodgkin lymphoma and non
acute leukemias
-blasts predominant
-short and drastic course
-AML-myloids
ALL-lymphoblasts (pre t and b)
ALL
acute lymphoblastic leukemia
-children
-neoplastic transformation of stem cells
-lymphoblasts in BM
-suppression of normal hemopoiesis
B=80 T=20
AML
acute myeloid leukemia
-adults
-myeloblasts: monoblasts, eosinoblasts, megakarloblasts, proerythroblasts, basophiloblasts
-auer rods
malignancy
myloblasts
unipotent stem cell- differentiate into granular series
auer rods
clumps of asurophillic granular material that form elongated needles
chronic leukemias
-more mature cells
-middle age
-longer, less devastating course
CLL
chronic lymphocytic leukemia
-adults in west
-monoclonal lymphoproliferative disorder
-lymphocytosis
-lymphadenopathy
splenomagaly
-smudge cells
-uncontrolled proliferation of myeloid cells
CML
chronic myeloid leukemia
-sustained granulocytosis with immature cells,
-bone marrow pathology
CML symptoms
-non specific
-hypermetabolism (high cell turnover)
-splenomegaly
CML course
-chronic phase (3-4)
-accelerated phase
-blast crisis/ myeloid or lymphoid (less 1)
CML therapy
chemo
BMT
philadelphia chromosome
hybrid chromo. with translocation bw long arm of 9 and long arm of 22
-may be present in granulocyte, RBC, platelet precursors