Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
|
Drug testing vs drug screening?
|
Testing: the most precise sense refers to quantitative analysis of bodily tissues or fluids to determine concentrations of particular substances Screening: the qualitative analysis of body tissue or fluid to broadly determine the presence of particular substances. |
|
|
Residence time in hair and nails, blood, saliva, urine and sweat? |
Hair and nails: days ~ years Blood: minutes ~ hours Saliva: minutes ~ hours Urine: minutes ~ days Sweat: minutes ~ weeks |
|
|
Methods of drug testing? |
Breath test: alcohol Blood, urine, saliva: same basic technology Hair: record of drug use, approx when drugs were taken |
|
|
Analysis sequence? |
* Observations: rock like, powdered, liquid? * Screening test: a presumptive test used to reduce the number of possible identities of an unknown substance (e.g. using Marquis reagent and Mandelin reagent (heroin/morphine, MDMA/ecstasy, Amphetamines/meth)) * Confirmation in lab |
|
|
Preliminary analysis: Microcrystalline tests? |
Can be used to identify specific drug substances by studying the size and shape of crystals formed when the drug is mixed with specific reagents. |
|
|
Confirmational determination? |
Infrared spectrophotometry Gas chromatography-mass spectrometry LC-MS/MS ..is used to specifically identify a drug substance |
|
|
Qualitative vs Quantitative? |
*Chromatography is a means of separating and tentatively identifying the components of a mixture. *TLC uses a solid stationary phase usually coated onto a glass plate and a mobile liquid phase to separate the components of the mixture. *Gas chromatography *UPLC-MS/MS *UV and IR spectrophotometry |
|
|
What is immunoassay based on? What is it used to analyze most commonly? How is it operated? |
- Antigen-antibody binding specificity. - Urine. - Antibody is produced by injecting antigen (drug) into a rabbit and then antibodies will bind to drug in urine. |
|
|
False positives for immunoassays? |
poppy seeds, pain killers for opiates decongestants and ephedrine for amphetamines benadryl, cough syrups for PCP melanine metabolites for THC |
|
|
How can you fool tests? |
Substitute Catheter Salt Detoxifier |
|
|
Nitrite in pee? |
Nitrite and nitrate are different, nitrate does not interfere. Normal nitrite concentrations in urine is well below 500 mcg/ml Nitrite is an oxidizing agent and may deteriorate with time in unpreserved urine. C of nitrite is high in adulterated urine. |
