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12 Cards in this Set
- Front
- Back
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Allostery |
-Other State -Binding ligand at one site affects binding properties of another site |
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Modulators/effectors |
Ligands that effect binding at another site |
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Homotropic modulator |
modulator is same as the ligand whose binding is effected
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Heterotropic modulator |
modulator is different that ligand whose binding is effected |
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Hill equations |
θ = [L]^n/([L]^n + Kd), Kd = [L(.5)]^n θ = [pGas]^n/([pGas]^n + p50^n) |
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Structural change upon O2 binding Hb |
-Heme sandwiched between E and F helices -When O2 binds F helix binds in a very small way |
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H+ Allostery with Hb |
-CO2 produced by respiration changes binding curves -At a given pO2 as H+ increases, (pH decreases) [T]/[R] increases, O2 affinity decreases -Binding deceases O2 affinity |
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CO2 Allostery with Hb |
-4 binding sites -CO2 binding releases an H+ -Stabilizes T-state -CO2 increase favors O2 release & vice versa -Hb transports ~20% CO2 in tissues |
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BPG Allostery with Hb |
![-1 site per Hb
-Stabilizes T-State
-[BPG] increases at higher altitudes
-Binds to + site in T state, in R state this site dissapears](https://images.cram.com/images/upload-flashcards/71/75/12/13717512_m.png)
-1 site per Hb -Stabilizes T-State -[BPG] increases at higher altitudes -Binds to + site in T state, in R state this site dissapears |
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High Altitude Adaptation |
-More erythrocytes -More Hb per cell -Increased BPG synthesis and concentration |
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Adult vs. Fetal BPG |
-Fetal Hb binds BPG w/ lower affinity -BPG crosses placenta -Lets mom drop off O2 to fetus |
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CO Allostery with Hb |
-CO binds heme group at same position as O2 -Binds w/ much higher affinity than O2 -Death when ~60% Hb is Hb-CO |
