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43 Cards in this Set

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Neurons have 4 zones for information processing:

1. Input zone: Dendrites receive signals from neighboring neurons The Nervous System How the Nervous System Works 


2. Integration zone: Cell body (soma) contains the nucleus where inputs are combined and integrated 


3. Conduction zone: Axon ex...

1. Input zone: Dendrites receive signals from neighboring neurons The Nervous System How the Nervous System Works




2. Integration zone: Cell body (soma) contains the nucleus where inputs are combined and integrated




3. Conduction zone: Axon extends away from the cell body transmitting the signal integrated at the soma




4. Output zone: Axon terminals (synaptic bottons) are the neurons output zone. They allow signals to be released from one neuron in order to reach another

The Synapse: x3 components

Presynaptic Membrane, 
Postsynaptic Membrane, and 
Synaptic Cleft 

Neurons communicate at synapses Stimulation of the neuron results in release of neurotransmitters from the presynaptic neuron 

Neurotransmitters can be: 
Excitatory: GlutamateInh...

Presynaptic Membrane,


Postsynaptic Membrane, and


Synaptic Cleft




Neurons communicate at synapses Stimulation of the neuron results in release of neurotransmitters from the presynaptic neuron




Neurotransmitters can be:


Excitatory: GlutamateInhibitory: GABA

Myelin


Glial cells ?


process? how long?
functions ? x2


node of ranvier ?

Glial cells are wrapped along the length of many axons forming Myelin




The process of forming Myelin is called Myelination and may not be complete until 10-15 years after birth




The gap between two segments of myelin sheathing is a node of ranvier




2 functions of myelin: 1. protect axons 2. increases speed of signal transduction along the axon

Divisions of the Nervous System


Natural subdivision between two general parts of thenervous system:

1. Central Nervous System(CNS): Brain and Spinal Cordall contained within thebones of the skull and spinalcolumn 


2.Peripheral Nervous System(PNS): All the nerves outsideof the spinal column

1. Central Nervous System(CNS): Brain and Spinal Cordall contained within thebones of the skull and spinalcolumn




2.Peripheral Nervous System(PNS): All the nerves outsideof the spinal column

Divisions of the PeripheralNervous System (2)

1. Somatic Nervous System:Part of the nervous system that interacts with the external environment.




2. Autonomic Nervous System:Part of the PNS that controls the body’s internal environment. A regulatory system that controls the internal organs.

Somatic Nervous System


Includes (2) types of nerves: +signals

1. Spinal Nerves


Nerves can be...


afferent: carry signals to the CNS (sensory)efferent: carry signals away from the CNS (motor) EXIT




2. Cranial Nerves

Autonomic Nervous System


2 Divisions of the Autonomic Nervous System:


think of automatic functions**
what regions????

1. Sympathetic-“fight or flight response” prepares the body for action- nerves generally arise from the thoracic and lumbar regions




2. Parasympathetic-prepares the body for rest and recovery-nerves generally arise from cranial and sacral regions

“fight or flight response” x4 biological reactions

Saliva production:decreased




Increases heartrate




Inhibits digestion




Stimulates hormone release from theadrenal gland -increases release of stress related hormones

Autonomic Nervous System3 Important principles

1. Sympathetic nerves stimulate, organize and mobilize resources in response to threat. Parasympathetic nerves conserve energy (subdiv)




2. Organs receive both opposing sympathetic and parasympathetic activation the response of the organ depends on the level of sympathetic vs parasympathetic input at the time.




3. Sympathetic changes - Psychological Arousal Parasympathetic changes - Psychological Relaxation

Diagram, memorize it and draw

The Central Nervous System - The Forebrain Two main subdivisions
*****

1. Telencephalon - Cerebrum(lobes) and hippocampus




2. Diencephalon - Thalamus and Hypothalamus


Thalamus - relay station between your senses and the rest of your nervous systemHypothalamus - maintains homeostasis, important in stress response, controls, eating,drinking, motivation

The Central Nervous System - The Cerebellum
Ataxia ?

Helps coordinate our movement and balance




Ataxia - movements that are uncoordinated and jerky




Symptom of many conditions:strokeMultiple SclerosisAlcohol abusemedications - barbiturates, benzodiazepinesvitamine deficiency (B12)Hereditary ataxias

The Central Nervous SystemThe BrainstemFour parts:
*******

1. Midbrain - top of brainstem, info from auditory and visceral (internal organs)system. 

3. Pons - Facial movements, controlling the eyes, swallowing 

4. Medulla Oblongata - breathing, heart rate: damage often life threatening

  2. Reticul...

1. Midbrain - top of brainstem, info from auditory and visceral (internal organs)system.




3. Pons - Facial movements, controlling the eyes, swallowing




4. Medulla Oblongata - breathing, heart rate: damage often life threatening




2. Reticular activating system - neurons that span the brainstem -controlling arousal and consciousness (damage coma)

The Central Nervous System - The Spinal Cord

Responsible for messages between the brain and the body




Efferent neurons - information away (exit)from the brain




Afferent neurons - information toward thebrain




Consequences of spinal damage demandon the region (high vs low) and severity(crushed, severed)

The Endocrine System
communicates how?

Both CNS and endocrine systems communicate with the rest of the body




CNS - electrical and chemical communication: quick (NT’s)


Endocrine - chemical communication: slower (hormones)



1. Endocrine and Nervous Systems Working Together
how?

The CNS and the endocrine system are linked via projections from the hypothalamus to the pituitary (hypophysis)




Hormones control critical physiological functions:reproduction, blood pressure, growth, appetite

Particularly relevant to this course:


The hypothalamic - pituitary - adrenal axis
*****VERY IMPORTANT, REVIEW AND MEMORIZE slide 17

https://www.youtube.com/watch?v=DduN12D019M



2. Adrenal Glands
Chronic high levels of what neurotransmitters produces what side effects???

Release hormones
Cortisol - in response to stress, reduces swelling




Epinephrine and Norepinephrine - work with CNS to alter heart rate, respiration rate




Chronic high levels of these types of hormones is associated with health side effects- hypertension- ulcers

3. Other Glands x3

Thymus gland - important in antibody production in early development




Thyroid gland - produces thyroxine=activity level/growth

disorders involving the thyroid include:


hypothyroidism - insufficient secretion of TSH (thyroid stimulatinghormone) or thyroxine. Low activity, weight gain, cognitive impairment,stunting of growth


hyperthyroidism - excess secretion of TSH or thyroxine. High activitylevels, weight loss, insomnia, anxiety, irritability, increased thirst/urination




Pancreas - regulates blood sugardiabetes - pancreas doesn't secrete enough insulin to remove sugarfrom the blood

The Digestive System


1. Digesting FoodTwo types of digestion
5 steps of digestion



1. mechanical - chewing, peristalsis




2. Digestion begins in the mouth - chewing and saliva contains enzymes




Down esophagus - peristalsis contraction




3. Stomach - gastric juice (acidic HCL) and pepsin (breaks down proteins) *churns*3-4hrs semi liquid mixture




4. peristalsis->Duodenum
- alkaline, from various organs


pancreatic enzymes break down (carbs,proteins and fats), absorption of nutrients increases


Small intestine




5. Large intestine and Colon - absorption of water 1st half, feces and elimination

2. Disorders of the Digestive System x6

Ulcers - sores on the lining of the stomach and small intestine causes: bacterial infection, too much acid. Characterized by abdominal pain Related to Stress




Irritable Bowel Syndrome - gastrointestinal disorder of no known cause. Characterized by bloating, abdominal pain, abnormal bowel movements
Related to Stress




Hepatits - viral diseases leading to liver inflammation


hepatitis A - water and food


hepatitis B and C - bodily fluids, sexual contact, transfusions, IV drug use




Cirrhosis - tissue damage to the liver impairing its function. Related to hepatitisand alcohol abuse




Inflammatory Bowel Disease - includes chrones and ulcerative collitis both are autoimmune disorders targeting the digestive system




Cancer - any part of the digestive tract

How does absorption occur?

Intestine wall has many folds that contain projections




The two projection contains a network of structures thatwill accept the molecules and transport them away to other parts of the body




These structures include tiny blood vessels called cappillaries and tube called a lacteal




Capillary- absorb amino acids, simple sugars, and water aswell as fatty acids, vitamins and minerals




Lacteals accepts glycerol and the remaining fatty acids andvitamins

Three principle outcomes of metabolism...
what is metabolism???

refers to all chemical reactions that occur in the body's cells




synthesis- build and repair body


regulation- producing enzymes and hormones


energy- heat the body and fuel activities

The Respiratory System
what's breathing do? x2

Breathing provides body with oxygen (required for metabolism) and eliminates waste (carbon dioxide)

The Respiratory System


The Respiratory Tract process x 4 steps
+2extra pts,.




what makes the air go in and out??

Air in - nose and mouth 
past larynx 
down trachea 
into bronchi (bronchial tubes) 
into lungs

  bronchial tubes divide into smallerbronchioles which terminate in tinylittle alveoli (important in gasexchange (oxygen and carbondioxide)  

  Diaphr...

Air in - nose and mouth


past larynx


down trachea


into bronchi (bronchial tubes)


into lungs




bronchial tubes divide into smallerbronchioles which terminate in tinylittle alveoli (important in gasexchange (oxygen and carbondioxide)




Diaphragm is important for maintaining negative pressure required for breathing

Respiratory Functions and Disorders


Respiration is required for...

The respiratory system can prevent foreign particles from entering the lungs and blood stream via 2 reactions

maintaining sufficient levels of oxygen in the blood to be delivered to tissues of the body via the circulatory system




1. reflexes sneezing or coughing


2. mucociliary elevator - mucus and cilia cause us to swallow foreign bodies and digest them

x4 respiratory diseases

pneumonia - bacterial or viral infection - inflammation and fluid



emphysema - destruction of alveoli decreasing gas exchange, which chronic bronchitis (COPD)




asthma - narrowing of bronchial airways




Cancer - lung, trachea, mouth

The Cardiovascular System
definition x2pts
x4 parts

Supplies the body with substances needed for normal function (nutrients,gases, immune factors, hormones etc)




Removes wastes of metabolism




1.The Heart and Blood Vessels


2. Blood Pressure


3. Blood Composition


4. Cardiovascular Disorders

The heart and blood vessels


Heart - definition
Has 4 chambers:


Arteries definition



muscle, the muscle wall is called the myocardium


4 chambers: 2 artia (atrium sing) at the top; 2 ventricles at the bottom


Arteries - carry blood away from the heartVeins - carry blood to the heart

Blood flow: 5steps

superior vena cava to right atrium (CO2 rich, O2 low)




right atrium to right ventricle to lungs (oxygenation)




lungs to left atrium (O2 rich, CO2 low)




left atrium to left ventricle




left ventricle out of aorta -> brain then body




https://www.youtube.com/watch?v=BEWjOCVEN7M

Blood ‘filtered’ by...
which does what 2 things??

liver and kidneys
liver=cleanse and store nutrients

Blood Pressure -




Blood pressure is reported as ...

force exerted by the blood on the artery walls




Resting force in the arteries (while the atria fill with blood) is called diastolic pressure


Heart pumps produces maximum pressure called systolic pressure




Blood pressure is reported as systolic / diastolic

5 factors that affect blood pressure

1. Cardiac output - volume being pumped




2. Blood volume - total amount of blood circulating




3. Peripheral resistance - width of blood vessels (smaller more pressure)




4. Elasticity - ability of blood vessels to expand and contract




5. Viscosity - thickness of the blood (thicker higher pressure)

The Cardiovascular System


Average volume
Blood Composition x2

4.7L




1.Formed Elements
Red Blood cells - formed in bone marrow;oxygen transportLeukocytes - white blood cells, different typesPlatelets - formed in bone marrow; clotting




2. Plasma~55% of our bloodcontains - water (90%), proteins, enzymes, hormones,waste products, nutrients, lipids,

Cardiovascular Disorders

Atherosclerosis - fatty plaques in vessels




Arteriosclerosis - elasticity of arteries is reduced




Myocardial Infarction - heart attack; due to lack of blood supply(oxygen) to the tissue of the heart muscle




Congestive Heart Failure - reduction in the ability of the heart to pump




Aneurysm - weakened section of blood vessel




Stroke - disruption of blood supply (oxygen) to part of the brain

The Immune System
x5 antigens, +definition

Antigen- any substance that can elicit an immune response




Bacteria - microorganism in the environment




Fungi - attach to a host and absorb nutrients (ringworm)




Protozoa - single celled organism - malaria




Viruses - many types infect cells and alter their geneticmaterial- herpes, HIV, flu




Transplants - immune system will respond to transplantedtissue as ‘non self’ immunosuppressants needed

The Organs of the Immune System

Organs of the immune system -


lymphatic or lymphoid organs




Primary role in producing lymphocytes - originate in bone marrow


Bone marrow, thymus, lymph nodes, spleen




Lymph nodes - spongy tissue throughout the body; filters antigens and stores lymphocytes


Spleen - filters the blood and therefore antigens (lymph drains intobloodstream) and stores WBC


pg 48

Soldiers of the Immune System
WBC’s - Two types:
white blood cell

lymphocytes and phagocytes




Phagocytes - patrol for and destroy antigens; non-specific immunity


Two types: macrophages, neutrophils


Lymphocytes - specific immunity


two types: cell mediated and antibodymediated

Lymphocytes

Cell mediated - T cells WBC that mature in the thymus, many types. Somerecognize ‘infected’ cells and kill them (T-killer cells), others facilitate the immuneresponse (T-helper cells)




Antibody mediated - attack antigens on the outside of cells. B cells produce immunoglobulins (IgG, IgM, Ig….) identify and destroy by recruiting phagocytes,or neutralizing viruses

The Immune System
Defending the Body with an Immune Response
Lines of defense...

First line of defence - skin; antibodies and other microbial substances


*Anitgens enter the body:*




Second line of defence
- non specific and specific processes


Non - specific phagocytes present antigens to T cells that destroy infectedcells


Specific - antigen presented to B cells and helper T Cells identify the invader and produce antibodies




3rd line- killer T cells

The Immune System


Developmental Changes

Immunity changes with age


infants little immunity - becomes more effective throughout childhood certain types of immune cells functioning declines with old age

The Immune System


Lifestyle, stress and Immune Function

Nutrition, smoking, stress, exposure to infectious disease alter immunity

The Immune System


Autoimmune Diseases



Immune response directed at ones own body; rheumatoid arthritis (joints),Multiple Sclerosis (myelin)