Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
30 Cards in this Set
- Front
- Back
|
3 neurological disorders of Agrypnia Excitata
|
FFI
Morvan syndrome delirium tremens |
|
|
Agrypnia Excitata charcaterized by (2)
|
loss of SWS
sympathetic/NA hyperactivation |
|
|
Agrypnia=
Excitata= |
loss of sleep/chase sleep
permanent autonomic/motor activation |
|
|
common pathogenic mechanisms for Agrypnia Excitata
|
disfunction in thalamo-limbic circuits
for ffi: anatomical interruptions for MS/DT: functional interruption |
|
|
FFI ____(3 word) disease
|
hereditary, autosomal dominant, prion disease
|
|
|
sFI=
|
sporadic form of fatal insomnia
|
|
|
can sFI/FFI be transmitted to animals
|
yes
|
|
|
PrP(c) vs PrP(sc)
|
PrP(c): soluble, degraded by proteases
PrP(sc): insoluble, protease resistant, accumulates/polymerizes into amyloid fibers and precipitates=cell death |
|
|
PrP(c) turn into PrP(sc) via (3)
|
infection
genetic mutation spont sporadic processes |
|
|
PrPsc acts as a template to
|
cause PrP(c) to become PrP(sc)
ie) PrP(sc)=infectious agent |
|
|
Most patients complain of (2)
|
severe insomnia
disturbances of vigilance/drowsiness |
|
|
FFI show increase in ___ hyperactivity like increase in blood pressure, heart and respiratory rate, body temperature, perspiration, lacrimation, salivation, impotence
|
autonomic
|
|
|
Relatives report that patients changed in character and look (2)
|
apathetic, taciturn
|
|
|
-as disturbances get worse begin to show _____(2word) behaviors
-then develop disturbances of (3) |
-peculiar oniric-->hallucinatory state and display motor gestures seemingly related to the content of a dream
-gait, equilibrium and other motor disorders |
|
|
dysarthria=
dysphagia= |
motor speech disorder
difficulty in swallowing |
|
|
can you die from ffi
|
yes
|
|
|
PSG of FFI:
-lose _____&___(N2) -lose ____&___(N3) -if you give barbiturates can you restore above -what happens to total S time -presence of subwakefulness shows ___activity |
-sleep spindles, K complexes
-sws, slow waves -no -decreases -theta |
|
|
FFI show increased plasma levels of __(2)
what happens to melatonin peak |
cortisol/NA
decreases |
|
|
(2) nuclei of thalamus have 50-80% neuron loss/ reactive___
|
anterior ventral&mediodorsal nuclei
astrogliosis |
|
|
_____also has 50% neuron loss/reactive astogliosis
|
inferior olive
|
|
|
loss of purkinje/granule cells and mild astrogliosis in _____during FFI
|
cerebellum
|
|
|
spongy degeneration and astrogliosis in ___for FFI
|
cortex
|
|
|
neuronal loss or spongiosis which occurs first in FFI
|
neuronal loss
|
|
|
mediodorsal nuclei of thalamus is involved in the transmission of
|
sleep spindles from the Reticular Thalamic Nucleus to the cortex
|
|
|
Damage of AV/MD nuceli and their projection to the cingulate cortex (thalamo‐cingulate system) cause (2)
|
hypovigilance and sleepiness
|
|
|
cure for FFI?
|
none
|
|
|
manage FFI, to improve quality of life, with (5)
|
vitamins
sedative hypnotics sensory deprivation at night exercise/stimulant in day ECT |
|
|
ECT improves the patient’s ability to sleep, side effects=(2)
|
memory loss
cognitive damage |
|
|
In MS, autoantibodies against ____ may affect the limbic system
|
voltage‐gated K channels
|
|
|
In DT, sudden changes in ____synapses down‐regulated by chronic alcohol abuse may affect the limbic system
|
GABAergic
|
