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26 Cards in this Set
- Front
- Back
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Ganesh |
Hindu god of wisdom and science |
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David Raftos |
reject tissue from unrelated donor tunicates, second rejected faster |
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Irv Weissman |
fusion of colonies of same genotype |
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Fester |
Fester recognition of fuHC probably initiates rejection or fusionq |
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Sushruta |
surgical transplant of skin |
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Gasparo Tagliacozzi |
reconstruct nose and earlobes, rejection by unrelated donors |
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Eduard Zirm |
transplanted cornea to restore vision to blinded patient |
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Ronald and Richard Herrick |
Donated a kidney to brother, successful for first time |
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Peter Medawar |
tolerance of organ transplant can be aquired |
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Milan Hasek |
tolerance between transplanted chick embryos |
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Autologous |
transplant of individuals own cells or organs |
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Syngeneic |
transplant between genetically identical individuals |
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Congeneic |
transplant between individuals that differe at only one locus |
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Allogeneic |
transplant between unrelated individuals of species |
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Xenogeneic |
Between different species |
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Orthotopic |
transplant at normal site |
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Heterotopic |
transplant at abnormal site |
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Geroge Snell Jackson |
Evidence of immune rejection of grafts |
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What recognizes foreign MHC? |
Allospecific T cells |
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How do allo-MHC recognize? |
Foreign peptide, self MHC binding - normal recognition Peptide independent binding - high affinity Peptide dependent binding- high affinity |
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Major histocompatability |
MHC on donor cells recognized by self T cells, fast response |
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Minor histocompatability |
Donor epitopes presented on self MHC, slow response |
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Priming of T cell response to transplant |
Donor DC migrate to LN, recognized by T cells, DAMP signals given to T cells, effector T cells move to transplant tissue |
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GVHD |
Converse of host response to graft get donor lymphocyte responses to host antigen |
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Chemotherapeutics to control GVHD |
Cyclosporin Methotrexate Steroids |
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Mixed chimerism |
Generate alloreactive Tregs that suppress immune activation |
