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25 Cards in this Set
- Front
- Back
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King Menes |
Died from bee sting |
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Britannicus |
Allergy to horse |
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King Richard III |
Strawberry allergy |
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John Bostok |
Seasonality to hay fever |
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Charles Richet and Paul Portier |
Jellyfish toxin sometimes had fatal reactions to same protein |
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Clemens von Pirquet |
Diphtheria anti-toxin had anaphylactic symptoms when treated with horse serum |
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Nicolas Arthus |
subcutaneous injection of horse serum into rabbits |
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Type I Allergy |
IgE |
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Type II Allergy |
IgG |
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Type III Allergy |
immune complex and complement mediated |
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Type IV |
T cell mediated |
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Allergy |
unwanted hypersensitivity response to an innocuous antigen |
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Hypersensitivity |
enhanced immune response to a previously encountered antigen |
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Atopy |
the environmental and genetic predisposition to developing allergy |
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Results of hypersensitivity |
Rhinorrhea - runny nose Sternutation - sneezing Inflammation - congestion |
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What needs "Good" Allergen
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protein, enzyme activity, low dose, low molecular weight, highly soluble, stable, bind MHC class II |
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Hygiene Hypothesis |
More hygienic means more prone to allergies due to a lack of building tolerance However, A may not cause B |
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H. Holbrook Curtis |
sublingual treatment with hayfever extract could reduce disease in patients |
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Leonard Noon and John Freeman |
increasing dose of Ag during repeated subcutaneous injection could desensitize patients |
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Philip Hench and Edward Kendall |
corticosteroid for inhibiting leukocyte function |
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Type II hypersenstivity |
production of IgG antibodies to cell surface proteins and granzymes dumped |
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Erythroblastosis fetalis |
Mom attach Rh on red blood cells of fetus but mom must be Rh-. Dad then must be Rh+ |
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Type III Hypersensitivity |
Complexes are recognized rather than cells |
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Type IV Hypersensitivity |
Delayed due to T cell response |
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Three types of Type IV hypersensitivity |
TB skin test, food allergy, poison ivy |
