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24 Cards in this Set
- Front
- Back
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BCR two main roles |
Signals that antigen is bound Engulfment of Ag to kill |
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What enhancing signal occur by bringing BCR and CR2 together? Its effect? |
PI3K (CD40-40L signal), induces up-regulation of costimulatory proteins to elicit T cell help |
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What do T cells and B cells recognize? |
T cells - peptide derived from the core B cells - surface epitopes |
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T-dependent B cell activation signals to activate T cells |
BCR/CR2 crosslinking from antigen recognition CD40, CD40L interaction |
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T-independent B cell activation signals |
Common microbial constituent activating B cell TLRs Massive crosslinking of BCRs by repetative structures |
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TI-type 1 antigens |
activate B cells without T cell help |
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High concentration of TI-1 Ag results in |
proliferation and differentiation of most B cells by binding nonspecific and producing polyclonal B cell responses |
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Low concentration of TI-1 Ag |
proliferation and differentiation of Ag specific B cells that is monoclonal antibody response |
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TI-2 antigen |
Have highly repetitive structures found on capsules of bacteria |
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Low density of TI-2 antigen |
not enough cross linking, no response |
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Medium density of TI-2 antigen |
Crosslinking occurs and activation occurs |
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High density of TI-2 antigen |
excessive crosslinking results in anergy |
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BLIMP-1 and its effect |
Transcriptional repressor required for B cell proliferation Become plasma cells and upregulate CXCR4 and a4b1 integrin that allows cell to leave LN |
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IgM location, function |
Blood, compliment by pentamers |
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IgG location, function |
Extracellular spaces and blood, opsin neutralization ADCC |
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IgA location, function |
Mucosal, neutralization |
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IgE location, function |
Epithelial, on mast cells of granulation |
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Neutralization |
Inhibit toxic effect by binding to the pathogen directly |
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Opsonization |
Coating pathogen, Abs increase phagocytic cells ability to engulf and destroy the pathogen |
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Complement Activation |
antibodies can trigger the activation of the classical complement system |
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Antibody-dependent Cellular Cytotoxicity (ADCC) |
Engagement of NK cells with antibody bound to pathogen causes cytotoxic granule release and pathogen killing |
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Antibiotic classifications |
Prevent bacterial cells from multiplying Kill the bacteria |
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What do antibiotics do? |
Block DNA replication and transcription Interfere with cell wall synthesis |
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ELISA |
Detect things in blood Coat with protein, flood with his serum, wash, wash detector Ab with enzyme, wash, and add substrate to change color |
