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15 Cards in this Set
- Front
- Back
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Consolidation
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memories must have time to consolidate in order to be long term
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Donals Hebb's theory
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memory stored in paired neural activity
cells that fire together wire together paired activity produces long term structural changes in the synapses |
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habituation- definition
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learned inhibition
reflexes habituate with repeated tactile stimulation |
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mechanism of habituation
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In aplysia there is a decrease in the EPSPs in the synapse between the sensory neuron from skin and the motor neuron of gill
caused by decreased glutamate |
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sensitization- definition
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learned facilitation
a harmful stimulus leads to a more vigorous response to other stimuli including harmless stimuli |
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specificity
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only synapses that are active during strong stimulation become strengthened
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cooperativity
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requires nearly simultaneous stimulation of 2 axons to generate LTP
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associativity
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pairing a weak input with a strong one enhances a later response to the weak input
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LTP and glutamate receptors
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glutamate binds to AMPA to let in sodium
NMDA is blocked w/ Mg after much stimulation and large depolarization, Mg is removed and glutamate binds to NMDA, which lets in sodium and calcium |
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role of calcium in LTP
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Calcium is needed to generate LTP
calcium causes a change in gene expression, which results in more AMPA and NMDA receptors as well as more synapses |
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mechanism of sensitization
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activation of facilitating interneuron
serotonin is released, causing increase responses from the withdrawal circuit serotonin blocks K, allowing for prolonged increase of neurotransmitter |
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long term memory formation can be blocked by preventing the synthesis of:
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mRNA
proteins (required to change synaptic structures) |
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hebbian synapses
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facilitated synapses
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Long term potentiation- definition
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a stable and enduring increase in the magnitude of response cause by high frequency stimulation
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properties of LTP
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specificity
cooperativity associativity |
