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23 Cards in this Set

  • Front
  • Back
The AALAS is a prefesonal, nonprofit association of people and institutions comcerned with the production, care and study of lab animals.
The use of animals for experimental research is a privelage extended by society extended to research institutions and their staff.
The institution and staff are obgliated to; 1 the animals are treated humanely. 2. the experiments are designed to answer a meaningful question. 3.use the least number of live animals, 4 limit unnecessary pain 5.justify using specific animals 5. no alternative is available to find out the information
Where does biomedical research get its funding?
most depends on numerous public and private sources
federal government 2/3
the instatutions themselves
funding from state governments
industry and private foundations 10%
Competitive federal grant programs are:
NIH , NSF, Mission agencies, private funding sources like Amercian cancer association, pharamcutical, industry.
National Institute of health
National Science Foundation
National Institute of Health-the primary granting agency through which the US conducts and supports biomedical research
National Science Foundation-federal agency created to develop and encourage the promotion of basic research in mathmatics, physics, medicine, biology,and behavorial and other sciences.
The United States Department of Agriculture requires that institutions in which certain species of experimental animals are used must be registered and must meet the standards created by the Animal welfare Act.
USDA makes unnounced visits
Food and drug administratiion is responsible for determining whether a new drug is safe and effective before it is approved for market in the US.
The Food ,Drug, and Cosmetic act of 1938 as ammended in 1962 states
the effectiveness of a drug or food additive for its intended use must be demonstrated by evidence that consists of thourough well controlled investigations. FDA issues directives that guide all aspects of drug development including animal tests and clinical phases.
Good Laboratory Practices (adopted by FDA in 1978) rules and implimented laboratory and audit program. Describe every aspect of the study.animal care enviromental control equipment maintance.
Laws that regulate importation and shipment of animals are written to protect human beings and the enviroment from potential harmful effects of disease carrying animals.
lab animals- must be shipped from country of orgin, necessary export documents and identification are provided, animals appear healthy, and they enter the us through designated ports of entry
Shipment of Etiological agents and animal vectors such as snails, bats, wild rodents are admissible by special permits.
USDA and some states have regulations that pertain to interstate sale and transportation of animals. dogs/cats
common lab rodents do not need health certificates but transport of sick or animals exposed to any transmissable disease from another state is prohibited.
several federal and state departments have regulations that prohibit or control transportation of wild animals.
potential disease carrying animals
Centers for disease control
transfer or import of etiologic or vectors of human disease insects bats wild rodents and others
Office of biosafty center of disease control
import od rumants , swine poultry other birds animal products tissues cell cultures etc
department of agruculture
import/export of wildlife
US fish and wildlife service
marine mammals
office of marine mammals and endangered species
Standard Operating Procedure
the Guide for the care and use of laboratory Animals

provides basic information on animal use for researchers

the standard used by theamerican association for the Accreditation of Lab animal care
The AAALAC uses the NIH guide or care and use of laboratory animals as a basis for site visiting animal facilities and evaluating the research being conducted in them