Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
What is the definition of osteoarthritis?
|
A disease that results in progressive and irreversible breakdown of articular cartilage
|
|
|
Is OA caused by abnormal stress on normal cartilage, or by normal stress on abnormal cartilage?
|
Both!
|
|
|
What causes cartilage breakdown?
|
Inflammatory stimulus --> IL-1
IL-1 is proinflammatory, and leads to degradation of cartilage matrix proteoglycans and collagen Cartilage matrix is in a catabolic state. |
|
|
What changes occur in the joint with OA?
|
Articular cartilage: degradation
Subchondral bone: sclerosis, lysis Joint capsule: fibrosis Synovial membrane: hyperplasia, hyperemia, increased synovial fluid production |
|
|
Where does pain originate in OA?
|
Inflamed synovial membrane
Inflamed fibrous joint capsule Inflamed subchondral bone |
|
|
What is the difference between SMOADs and DMOADs?
|
Symptom Modifying OA Drugs - decrease pain
Disease modifying OA Drugs - minimize the progression of OA |
|
|
How do NSAIDs help reduce OA pain?
|
Inhibit cyclooxygenase --> decrease prostaglandins, inflammation
|
|
|
How do corticosteroids help reduce OA pain?
|
Inhibit phospholipase A2, COX2 --> decreased inflamation
Given intraarticularly |
|
|
What can you combine with corticosteroids in joint injections that will help in treatment?
|
Hyaluronan
|
|
|
Which corticosteroid is anecdotally most effective?
|
Methylprednisolone
|
|
|
How long should horses be on stall rest after joint injection with corticosteroids?
|
Typically 7-10 days, followed by a gradual return to exercise over 7 days.
|
|
|
Why is hyaluronon (HA) helpful with OA?
|
Acts as an anti-inflammatory/mediates joint damage
Decreases chemotaxis, phagocytosis, lymphocyte stimulation, PG release Free radical scavenger May stimulate endogenous HA production. |
|
|
Why are polysulfated polysaccharides used for OA treatment? What class of drug are the in?
|
Considered "slow acting DMOADs"
Prevent, slow, reverse morphologic cartilage lesions Inhibit inflammation Adequan, GAG's |
