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41 Cards in this Set

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Clinical uses of Pilocarpine
Sjogren's and glaucoma
Edrophonium
alcohol, very short acting, 5-15 minutes, poorly lipid soluble
Drugs used in Myastenia Gravis
Edrophonium, Neostigmine, Pyridostigmine
Neostigmine
PO, 30 min-2hrs
Physostigmine
30 min-2 hours PO, Is lipid soluble
Parathion
very toxic, organophosphate, in pesticides
Clinical uses of Methscapolamine
GI and GU
Clinical use of Oxylbuthin
GU
Clinical use of Tolteradine
GU
Signs of Muscarinic Toxicity
Mad as a hatter, red as a beat

Can't see, can't pee, ...
Ephedrine
a1a2b1b2
mixed
oxymetazoline
nonselective alpha1 alpha2
Epinephrine
a1a2b1b2
mechanism of action of reserpine
blocking uptake of endogenous
mech of action of Guanethidine
competes with catecholamines for uptake; displaces Norepi from vesiicles
Name some direct acting adrenergic agonist?
PECTIN

Phenylephrine
Epinephrine
Clonidine
Terbutaline
Isoproterenol
Norepinephrine

Remember: Dobutamine
Name some non-selective direct acting adrenergic agonist?
Isoproterenol
Epinephrine
Norepinephrine
What are the types of Indirect- acting Adrenergic Agonists?
Releasing agents
Uptake Inhibitors
MAO/COMT Inhibitors
What are the types of Indirect-acting Adrenergic Agonist
Releasing agents, Uptake Inhibitors, MAO/COMT Inhibitors
Direct-acting, mixed-acting, and indirect acting are all types of ______ agonist
Adrenergic
How does prior treatment with reserpine or guanethidine affect the releasing agents, amphetamine and tyramine?
Responses are Abolished
Hoe does prior treatment with reserpine or guanethidine affect the mixed- acting agent, ephedrine?
Response is REDUCED
How does prior treatment with reserpine or guanethidine affect the direct-acting adrenergic agonist?
Responses are NOT reduced
sympathomimetic describe primarily _________ activation which is due to a drug substance binding the same receptors as ______, and acting as an ______.
adrenergic
Norepinephrine
agonist
____________ are valuable therapy for myastenia patients
cholinesterase inhibitors
__________ is sometimes used as a diagnostic test for myasthenia.
Edrophonium
After a patient with myastenia gravis is given Edrophonium, how will muscle strength changes?
an improvement in muscle strength that lasts about 5 minuutes is usually observed.
myasthenic crises must be distinguished from ___ ______
cholinergic crisis
Long term therapy for myasthemia gravis is accomplished with _______, ____________, or __________
neostigmine
pyridostigmine
ambenonium
Drugs used in the treatment of pheochromocytoma.
phenoxybenzamine
phentolamine
_______ receptor antagonist are most useful in the preoperative mangaement of patient with pheochromocytoma
alpha
Where is the tumor of pheochromocytoma found?
adrenal medulla
The tumor of pheochromocytoma releases a mixture of
epinephrine
norepinephrine
Uses of Bethanechol
Post-op and Neurogenic Ileus and Urinary Retention
Uses of Carbachol
Glaucoma
Uses of Pilocarpine
Glaucoma
Sjogren's Syndrome
Uses of nicotine
Smoking deterrence
Muscarinic Toxicity
CNS stimulation
Miosis, spasm of accomodation
Bronchoconstriction
Increases GI and GU smooth muscle activity
Increased secretory activity: sweat glands, airway, GI tract
Vasodilation,
reflex tachycardia
Nicotinic toxicity
CNS stimulation, including convulsions followed by depression

ganglionic stimulation and block

neuromuscular end plate depolarization leading to fasciculation and paralysis
cholinergic toxicity mnuemonic
D-Diarrhea
U- Urination
M- Miosis
B- Bronchoconstriction
B- Bradycardia
E- Excitation
L- Lacrimation
S-Salivation
S-Sweating
Agent used to treat insecticide poisoning. only agent available in the US
Pralidoxime