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18 Cards in this Set
- Front
- Back
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What is the most valuable initial test to order in a thyroid workup? |
1. TSH |
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What criteria must the patient meet in order for a TSH to be reliable? |
1. Intact axis 2. Stable pt with no recent tx for thyroid disease |
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What does T4 measure? |
1. Bound and unbound thyroxine |
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What does low T4 with increased TSH indicate? |
1. Primary hyperthyroidism |
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What does elevated T3 and T4 with decreased TSH indicate? |
1. Primary hyperthyroidism |
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What does a low TSH with normal/low T4 and a high T3 indicate? |
1. T3 thyrotoxicosis |
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What does a free T4 measure? |
1. Fraction of T4 not bound to protein--biologically active |
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How is a thyroid scan done? |
1. Radiolabeled iodine is ingested 2. 4-6 hours later the thyroid is scanned 3. Look for hot vs. cold thyroid nodules |
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What are the three major types of thyroid autoantibodies? |
1. Anti-tyroid peroxidase 2. Anti-thyroglobulin 3. Anti-TSH-receptor antibodies |
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What are the two types of TRAbs? |
1. TSI 2. LATS |
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What is the function of TPOAbs? |
1. Involved in tissue destruction in Hashimoto thyroiditis 2. Not specific for any one disease |
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When will TgAbs be seen? |
1. Hashimoto thyroiditis 2. Can be seen w/o thyroid disease |
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When is TgAb tested? |
1. If anti-TPO tests are negative 2. Test before assay for Tg |
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Of what are TRAbs indicative? |
1. Graves disease |
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What are the two types of TRAbs? |
1. Stimulating 2. Blocking |
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Undetectable levels of TSH, wither without T4 elevation=... |
1. Autoimmune hyperthyroidism 2. Toxic nodular goiter 3. Thyroxine overdose*** |
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When TSH is elevated, what generally happens to T4 in primary hypothyroidism? |
1. Depressed |
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What would an elevated T4 and TSH level mean? |
1. TSH-secreting pituitary adenoma 2. Ectopic production of TSH or TRH |
