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21 Cards in this Set
- Front
- Back
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Hemostasis
purpose |
1. stops bleeding
2. maintaining blood in fluid state |
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Two stages of hemostasis and end products
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1. Primary hemostasis: platelet plug
2. Secondary hemostasis: fibrin |
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von Willibrand disease
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- plts have impaired ability to adhere to the broken endothelium
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Agonists used to induce plt aggregation
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- ristocetin
- ADP - epinephrine - serotonin - collagen - thrombin |
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Systems involved in hemostasis
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- blood vessels
- plts (primary hemostasis) - coag factors (2ndary hemostasis) - fibrinolysis |
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von Willibrand factor is made by...
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megakaryocytes and endothelial cells when they get attached to GP1b
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What happens when there is a break in the vessel lining?
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- vasocontriction
- plt adhesion to collagen fibers |
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Process of platelet plug formation
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1. blood vessel injury
2. vascular response 3. plt adhesion (not need nrg) 4. plt aggregation (need nrg) |
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What happens to plt after adhesion?
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- shape change
- secrete ADP from electron dense granules - recruit more plts to injured site |
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Alpha granules produce?
Dense granules produce? |
alpha --> fibrinogen
dense --> ADP |
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Plt plug formation = plt aggregation is aka?
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viscous metamorphosis
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How do decreased plt numbers or function affect plt plug formation?
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- takes longer to form plt plug
- functionally abN plt |
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What systems are involved in the coag cascade?
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- Intrisic System
- Extrinsic System - Common Pathway System |
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Where does tissue factors come from in Extrinsic System?
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Broken endothelial
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Where does the factors come from in Intrinsic system?
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all necessary factors for fibrin formation are present in the blood
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Fibrinolysis
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gradual and enzymatic breakdown of fibrin into soluble fragments
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D-dimer is specfic to?
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breakdown product of fibrin
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Reasons for factor deficiency in plasma.
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1. Decreased synethsis
2. synthesis of a dysfunctional factor 3. excessive destruction of blood coag factors 4. destruction of factors by circulating inhibitors |
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Coag factors in Intrinsic System
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XII
XI IX VIII |
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Coag factors in Extrinsic System
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VII
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Coag factors in Common Pathway System
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X
V II I |
