Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
14 Cards in this Set
- Front
- Back
|
4 types of CMPDs.
|
CML - Chronic Myeloblastic Leukemia
PV - Polycythemia Vera ET - Essential Thrombocythemia IMF - Idiopathic Myelofibrosis |
|
|
General characteristics of CMPDs
|
Hypercellular b.m.
Increased quantities of some or more cell lines 60-90% pts have splenomegaly Clonal |
|
|
Clinical and hematological features of CMPDs
|
middle age and older groups
extra-meduallary hematopoiesis -> spleen and liver may terminate in Acute Leukemia Frequent transition between CMPDs Cytogenic abN Molecular abN |
|
|
IMF characteristics
|
fibrosis of the marrow
extra-meduallary hematopoiesis or myeloid metaplasia leukoerythroblastosis dacryocytes present No cure |
|
|
IMF pathogenesis & current theory
|
increased acculmulation of marrow collagen
plts are implicated calcitrol |
|
|
calcitrol
|
inhibits collagen synthesis by suppressing megakaryocyte proliferation
|
|
|
PV laboratory findings
|
^^ rbcs in pb and bm + excessive proliferation of myeloid & plt elements
|
|
|
PV pathogenesis
|
- origin of PV is an abN pluripotent stem cell
|
|
|
PV lab features
|
1. ^rbc/^hct/^hb
2. EPO N or decrease 3. rbcs are N/N 4. ^plts (50%)/^granulocytes(68%) 5. falsely elevated PT and APTT tests 6. ^LAP (70%) 7. splenomegaly is present |
|
|
PV risks
|
1. in vivo clotting
2. transformation into IMF or leukemia |
|
|
PV treatment
|
to reduce rbc mass
- phlebotomy - myelosuppressive drugs |
|
|
ET characteristics
|
1. marked thrombocytosis
2. plts have abN plt function 3. quite rare 4. 2/3 pt no sym, 1/3 bleeding sym |
|
|
ET lab features
|
1. plts >600 x 10^9/L
2. PDW ^ (usually <20) 3. abN plt aggregation pattern 4. prolonged bleeding times 5. megakaryocytic hyperplasia in bm 6. ph chromosome is absent |
|
|
ET treatment
|
1. plateletpheresis
2. chemo |
