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10 Cards in this Set
- Front
- Back
basic structure of LA
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1. intermediate carbon
2. unsaturated (aromatic ring ) 3. tertiary amine |
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aromatic ring (benzene) is
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lipid soluable
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tertiary or quaternary amine depends on ?
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pH and pka
provides hydrophilic characteristics partially charged at physiologic pH(7.4) |
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contains either ester or amide linkage
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intermediate carbon group
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linkage of eith ester or amide determines
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metabolic and
allergic potential |
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binds aromatic ring to carbon group
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intermediate carbon group
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metabolized in the liver
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amino amides
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metabolized by plasma cholinesterases
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amino esters
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amount of LA compound that exists in each form determined by?
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ph of environment
pka of drug |
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all clinically used LA are
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weak bases
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