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58 Cards in this Set

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NaHCO3
Antacid: acid neutralizing agent
CaCO3
Antacid: acid neutralizing agent
Al (OH)3
Antacid: acid neutralizing agent
Mg (OH)2
Antacid: acid neutralizing agent
Charcoal
antiflatulents
Smethicone
antiflatulents
cimetidine
(TAGAMENT)
H2-Receptor Antagonist
Ranitidine
(ZANTAC)
H2-Receptor Antagonist
Famotidine
(PEPCID)
H2-Receptor Antagonist
Nizatidine
(AXID)
H2-Receptor Antagonist
H2-Receptor Antagonist (4)
Cimetidine (TAGAMET)
Ranitidine (ZANTAC)
Famotidine (PEPCID)
Nizatidine (AXID)
Proton Pump Inhibitors (5)
Omeprazole (PRILOSEC)
Lansoprazole (PREVACID)
Rabeprazole (ACIPHEX)
Pantoprazole (PROTONIX)
Esomeprazole (NEXIUM)
sucralfate
(CARAFATE)
Mucosal Protective Agent

aluminum sucrose sulfate: activated by stomach acid and binds to duodenal ulcers; a barrier to persistent acid damage.
bismuth salts
Mucosal Protective Agent

similar to sucralfate, but may decrease the action of H. pylori in peptic ulcer disease.
misoprostol
(CYTOTEC)
Mucosal Protective Agent

analog of prostaglandin E1, decreases stomach acid production and may increase mucous and bicarbonate secretion. Contraindicated in pregnancy.
Alginic Acid
(GAVISCON)
Mucosal Protective Agent

polymer from seaweed, floats and protects esophagus from gastric acid; a component of antacids.
Metoclopramide
(REGLAN)
Drug Promoting Gastric Motility

antagonize enteric dopaminergic receptors which enhance release of Ach, increasing gastric motility.
Cisapride
(PROPULSID)
Drug Promoting Gastric Motility

5-HT4 agonist, which also stimulates myenteric Ach release (restricted use due to toxicity).
Erythromycin
Drug Promoting Gastric Motility

stimulates motilin receptors, with increased gastric emptying, but increased incidence of diarrhea reported.
Benzodiazepines
Antiemetic drug

anxiolytic effect reduces anticipatory nausea and vomiting.
Dexamethazone
Antiemetic drug

effective adjunct in tx of N&V in chemotherapeutic regimens.
Dronabinol
(MARINOL)
antiemetic effect is primarily central (CTZ)
Emetrol
Phosphorated carbohydrate solution (EMETROL) reduce smooth muscle contraction.
Metoclopramide
(REGLAN)
Antiemetic Drug:

Dopaminergic Antagonists
Prochlorperazine
(COMPAZINE)
Antiemetic Drug:

Dopaminergic Antagonists
Promethazine
(PHENERGAN)
Antiemetic Drug:

Dopaminergic Antagonists
Ondansetron
(ZOFRAN)
Antiemetic Drug:

5-HT3 Antagonists

Antagonize 5-HT-mediated N&V centrally and peripherally.
Dolasetron
(ANZEMET)
Antiemetic Drug:

5-HT3 Antagonists

Antagonize 5-HT-mediated N&V centrally and peripherally.
Granisetron
(KYTRIL)
Antiemetic Drug:

5-HT3 Antagonists

Antagonize 5-HT-mediated N&V centrally and peripherally.
Aprepitant
(EMEND)
Substance P/Neurokinin 1 (NK1) Receptor Antagonists

-an antagonist of NK1 receptors, reducing vomiting associated with activation of these receptors.
-Useful in emetogenic chemotherapy (such as cisplatin). PO administration. Used concurrently with 5-HT3 antagonists and dexamethasone.
Castor oil
Stimulant Laxative

ricinoleic acid increases intestinal motility
-Used as a component for bowel preparation.
Cascara & Senna
Stimulant Laxative

contain plant alkaloids which stimulate colonic motility.
-Used as a component for bowel preparation.
phenophthalein & bisacodyl
Stimulant Laxative

synthetic colonic stimulants
-Used as a component for bowel preparation.
Psyllium seed
(METAMUCIL)
Bulk Forming Laxatives
-Increase intralumenal fluid, indirectly stimulating peristalsis (bowel prep, reduce impaction).
Methylcellulose
Bulk Forming Laxatives
-Increase intralumenal fluid, indirectly stimulating peristalsis (bowel prep, reduce impaction).
Bran
Bulk Forming Laxatives
-Increase intralumenal fluid, indirectly stimulating peristalsis (bowel prep, reduce impaction).
Saline cathartics
(FLEET’S PHOSPHO-SODA)
Bulk Forming Laxatives
-Increase intralumenal fluid, indirectly stimulating peristalsis (bowel prep, reduce impaction).
Sorbitol
Bulk Forming Laxatives
-Increase intralumenal fluid, indirectly stimulating peristalsis (bowel prep, reduce impaction).
PEG solutions
Bulk Forming Laxatives
-Increase intralumenal fluid, indirectly stimulating peristalsis (bowel prep, reduce impaction).
Lactulose
Bulk Forming Laxatives
-Increase intralumenal fluid, indirectly stimulating peristalsis (bowel prep, reduce impaction).
Mineral oil
Stool Softners
-Emulsification of intralumenal contents reduces pressure for defecation, esp. in cardiac rehab, diverticula, etc
glycerin suppositories
Stool Softners
-Emulsification of intralumenal contents reduces pressure for defecation, esp. in cardiac rehab, diverticula, etc
docusate
(Colace)
Stool Softners
-Emulsification of intralumenal contents reduces pressure for defecation, esp. in cardiac rehab, diverticula, etc
Diphenoxylate
(LOMOTIL)
Antidiarrheal agent
Loperamide
(IMODIUM)
Antidiarrheal agent
-presynaptic opiate receptors inhibit Ach release, and associated peristalsis.
Kaolin & Pectin
(KAOPECTATE)
Antidiarrheal agent
-bind bacteria and associated toxins which increase peristalsis.
Bismuth subsalicylate
(PEPTO BISMOL)
Antidiarrheal agent
-may inhibit binding of enteric E. coli toxins to mucosa.
5-ASA or Mesalamine
(PENTASA)
Management of IBS
Salicylate Derivatives

-all agents deliver 5-ASA to the colon as an anti-inflammatory agent.
Sulfasalazine
(AZULFIDINE)
Management of IBS
Salicylate Derivatives

-all agents deliver 5-ASA to the colon as an anti-inflammatory agent.
Olsalazine
(DIPENTUM)
Management of IBS
Salicylate Derivatives

-all agents deliver 5-ASA to the colon as an anti-inflammatory agent.
Balsalazide
(COLAZAL)
Management of IBS: Salicylate Derivatives

-all agents deliver 5-ASA to the colon as an anti-inflammatory agent.
Hydrocortisone
(CORTENEMA and CORTIFOAM)
Management of IBS: Immunosuppressants

-given as retention enema/foam, reduces systemic effects. Other steroids may be used as well.
Azathioprine & Mercaptopurine
Management of IBS: Immunosuppressants

-cytotoxic drugs which, at low doses, inhibit the inflammation and minimize hematologic effects.
Infliximab
(REMICADE)
Management of IBS: Immunosuppressants

-monoclonal antibody against TNF-alpha, a mediator of the granulomatous inflammatory process in Crohn’s Disease.
Alosetron
(LOTRONEX)
Agents for IBS

-5-HT3 antagonist for diarrhea-prominent IBS. Restricted use due to ischemic colitis with this drug.
Tegaserod
(ZELNORM)
Agents for IBS

-5-HT4 agonist for constipation-prominent IBS. Diarrhea is SE.
Orlistat
(XENICAL)
Enteric Lipase Inhibitors

-inhibits enteric lipase resulting in decreased fat absorption.
-Primarily for weight loss.
-Reduces fat-soluble vitamin absorption.
-Increased defecation with fatty stool.
Lubiprostone
(AMITISA)
Idiopathic constipation

-Indicated for idiopathic constipation
-Activates an intestinal chloride channel resulting in the intralumenal increase in chloride and water in the GI lumen without significant absorption and effect upon serum fluid and electrolytes.
-Not recommended during pregnancy.