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25 Cards in this Set
- Front
- Back
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_____ are the energy currency of the cells.
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nucleotides
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_____ are used in the synthesis of activated intermediates in the synthesis of carbohydrates, lipids, proteins, and co-enzymes.
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nucleotides
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true or false
Nucleotides serve as second messengers in signal transduction pathways. |
true
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Nucleotides are _____ activators/inhibitors for a variety of pathways.
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allosteric
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Nucleotides are composed of what three components?
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nitrogenous base
ribose sugar energy containing phosphohydride bond |
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ribose sugar + nitrogenous base =
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nucleoside
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phosphates + nucleoside =
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nucleotide
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Ribose 5 phosphate (R5P) is from the _____ pathway.
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pentose phosphate
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To make a nucleotide, the NMP is _____ and, if necessary, _____ to form the deoxynucleotide.
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phosphorylated
reduced |
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true or false
The metabolism of the purines and pyrmidines are the same. |
false
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What are the two ways nitrogenous bases in nucleotides can be synthesized?
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de novo
salvage pathways |
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PRPP is an activated pentose that participates in the synthesis of _____ & _____ and _____ pathway of purine bases.
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purines
pyrimidines salvage |
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R5P + ATP makes what?
with what enzyme? |
PRPP + AMP
PRPP synthase |
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PRPP synthase is activated or inhibited by inorganic phosphate?
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acvtivated
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Purine nucleotides _____ PRPP synthase.
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inhibit
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Synthesis of ______ is the committed step in the synthesis of purine nucleotides.
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5'-phosphoribosylamine
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Negative effectors of the committed step of purine synthesis are...(name three)
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AMP
GMP IMP |
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_____ regulation insures GMP and AMP are made in correct amounts.
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coordinate
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AMP synthesis requires ____ for energy and synthesis of GMP requires ____.
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GTP
ATP |
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Base specific nucleotide monophosphate kinases synthesize ___ from corresponding ___.
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NDP
NMP |
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In the purine pathway, _____ occurs to form dNDP.
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reduction
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Nucleoside diphosphate kinase works with both ____ and ____.
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dNDPs
NDPs |
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ATP _____ ribonucleotide reductase and dATP _____ the enzyme.
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activates
inhibits |
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Sources of the atoms in the pyrimidine ring are ____, ____, & ____.
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glutamine
CO2 aspartic acid |
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The key regulatory step in pyrimidine synthesis is _____.
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the synthesis of carbamoyl phosphate by carbamoyl phosphate synthetase II
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