Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
47 Cards in this Set
- Front
- Back
|
Citalopram:
1. Indications 2. t/2 3. mechanism of action 4. Inhibition 5. unique properties 6. avoid with? max dose? |
1. Depression (FDA), Anxiety Ds, PreMenstrual Dysphoric Disorder
2. 1-2 days 3. serotonin reuptake inhibitor, most selective, mild h1 activity 4. 2d6 and 3a4 mild 5. most selective, and tolerable 6. MAOI's 60mg |
|
|
Escitalopram:
1. Indications: 2. Compared to citalopram? 3. t/2 |
1. Depression, GAD
2. 10mg more than 2X ... i.e., = to 40mg citalopram 3. 1 day (27-32h) max: 20mg (although can go to 30, 40mg even) |
|
|
which ssri most nauseating?
|
fluvoxamine
|
|
|
which ssri most anorexic?
|
fluoxetine
|
|
|
which ssri longest half life and how long?
|
fluoxetine, 1 week ; i.e., washout 5 weeks
|
|
|
most anticholinergic ssri?
|
paroxetine
|
|
|
most diarrhea ssri
|
sertraline
|
|
|
most sexual dysfxn ssri?
|
sertraline
|
|
|
few drug interactions?
|
sertraline
|
|
|
what are ssri side fx?
|
Psych: SI in youth and younger, anxiety, insomnia, sedation
GI: nausea, diarrhea, constipation neuro: headache autonomic: sweating, dizziness Sexual dysfunction |
|
|
what type of dose response curve is there in depression
|
flat
|
|
|
venlafaxine mechanism?
|
selective norepinephrine reuptake inhibitor
also 5HT & NE |
|
|
venlafaxine side fx?
difference betweeen SSRI's? |
dose related increase in bp
otherwise, similar to SSRI except less sexual dysfunction |
|
|
benzo's cause what type of amnesia?
|
anterograde
|
|
|
which benzo has multiple interactions?
|
alprazoloam (xanax)
|
|
|
alprazolam level changed by
|
fluvoxamine, grapefruit juice, ketoconazole, nefazodone,
level decreased by theophylline |
|
|
buspirone mech
|
5 HT1a agonist
|
|
|
buspirone indication?
|
GAD
|
|
|
hydroxyzine mech
|
antihistamine
|
|
|
moclobemide mech
|
Reversible inhibitor MAO
|
|
|
propranolol indication?
|
performance anxiety
|
|
|
clomipramine used for?
|
OCD ... because most serotonergic agent
|
|
|
how long to TCA's take for effect?
|
2-3 months
|
|
|
what amount of TCA considered fatal usually?
|
2 grams
|
|
|
which TCA most well tolerated?
|
desipramine
|
|
|
which TCA has most NE activity
|
desipramine
|
|
|
which TCA has least anticholinergic activity?
|
desipramine
|
|
|
what levels are used for TCA?
|
trough
|
|
|
what is alprazolam peak level and t/2
|
peak 1-2hours
half life 12hours |
|
|
ativan: peak levels time
1. PO 2. SL/IM 3. IV |
1. 1-4 hours
2. 1 hour 3. 5-10min |
|
|
which benzo's have least interaction?
|
LOT
|
|
|
which benzo has 100 hour half life?
|
chlordiazepoxide
clorazepate flurazepam |
|
|
half life of clonazepam?
|
34hours
|
|
|
clonazepam peak level?
|
1-4 hours
|
|
|
diazepam peak levels of
1. po 2. im 3. iv |
1. 1-2 hours
2. 1 hour 3. 8 minutes |
|
|
when is onset of short-half-life benzo WITHDRAWAL?
|
1-2 days
|
|
|
type of benzo amnesia?
|
anterograde
|
|
|
benzo tolerance develops more to?
|
greater tolerance to sedative effect, less than anxiolytic effect
|
|
|
benzo taper rate?
|
up to 25% per week
|
|
|
hypnotic length of therapy max?
|
4 weeks
|
|
|
benzo's combined with which drug is dangerous?
|
clozapine: major sedation, respiratory arrest
|
|
|
tx of benzo overdose?
|
flumazenil
|
|
|
benzo precautions (disorders to avoid in)
|
sleep disorder, sleep apnea, cognitive disorder, renal/hepatic dx, elderly,
porphyria cns depression myasthenia pregnancy (teratogen and withdrawal if used in 3rd trimester) |
|
|
carbamazepine: common side fx?
|
gi, unsteady, itchy rash, dcreased WBC (dose related)
|
|
|
carbamazapine rare side fx?
|
aplastic anemia
increased liver enzymes cardiac abn hyponatremia SLE dermatitis ocular problems persistent low WBC lower t3/4 alopecia weight gain: little |
|
|
carbazapine avoid in?
|
liver disease and mainly hepatically cleared
|
|
|
carbamazapine and relation to p450?
|
auto induces
|
