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28 Cards in this Set
- Front
- Back
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__ is the inflammation of the glomeruli.
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glomerulonephritis
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Inflammation of GN is characterized by infiltration by what 3 things?
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-leukocytes
-edema -vascular fragility |
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Glomerular disease may manifest by 3 major syndromes?
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-nephritic syndrome
-nephrotic syndrome -RPGN |
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__ syndrome consists of sudden onset of hematuria and nonnephrogenic range proteinuria, active sediment with RBC casts, ARF, and htn
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nephritic
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__ syndrome is characterized by heavy proteinuria, edema, hypoalbuminemia, and hyperlipidemia.
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nephrotic
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__ is characterized by active sediment (rbc casts) and rapid development of ARF usually over weeks to months
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RPGN
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GN is mediated by __ processes
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immune
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Immune processes of GN include the deposit of __ and complement within the glomerulus.
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antibodies
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__ accounts for the majority of progressive renal dx in many parts of the world.
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GN
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What are the s/s of GN?
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dysfunction of:
-filtering water and small solutes -providing a barrier impermeable to plasma proteins and blood cells |
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__ is the key manifestation of GN.
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hematuria
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Glomerular __ leads to glomerular hemorrage.
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inflammation
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__ casts are the hallmark of glomerular injury and are almost always present in acute GN.
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RBC casts
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Nephritic syndrome includes what s/s?
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htn
hematuria non-nephrotic proteinuria ARF |
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Nephrotic syndrome includes what s/s?
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htn
edema nephrotic proteinuria >3.5g/qd hyperlipidemia |
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RPGN s/s include what?
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hematuria
non-nephrotic proteinuria <1.5gm/qd ARF-rapid onset |
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What is a frequent sign of GN?
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htn
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What are 2 mechanisms that cause htn in pt's with GN?
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-renin release due to inflammation and impaired renal perfusion
-intravascular volume expansion caused by mineral corticoid-induced fluid retention and/or renal insufficiency. |
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Urine output may be diminished or __ in GN
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absent
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Nephritic syndrome is also called ?
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post streptococcal gn
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Suddenonset of gross hematuria, RBC casts, and nonnephrotic proteinuria are classic signs of __?
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post strep gn
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When do sx's of psgn show themselves?
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frankly i do not give a shit at this point! But..
-1-2 weeks after pharyngitis -3-6 weeks after a skin infection |
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What are commonly seen s/s of nephritic syndrome (psgn)?
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wt gain with edema
htn-can be malignant falnk or abd. pain dec. urine output and ARF |
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In PSGN (nephritic syndrome) the crt level does not normally go above __?
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4mg/dL
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T/F
RPGN is a clinical syndrome rather than a pathological diagnosis. |
true
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__ is defined as loss of renal fcn of more than __% over a period of 3 months in pts with hematuria & proteinuria.
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RPGN
50% |
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Membranous glomerular disease is also called...?
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nephrotic syndrome
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During what decades in life does nephrotic syndrome typically present itself?
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3-5 decade
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