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139 Cards in this Set

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  • Back
The posterior thyroid cartilage has a superior and inferior cornuae. What do they both attach to?
Superior cornuae - thyroid ligaments connect it to the hyoid bone

Inferior cornuae - articulates with the cricoid cartilage
Superior cornuae - thyroid ligaments connect it to the hyoid bone

Inferior cornuae - articulates with the cricoid cartilage
Which cartilage is the strongest of the laryngeal cartilages?
Cricoid cartilage (the only complete ring in the airway)
What does the shape of the cricoid cartilage resemble?
A signet ring (flat and wide posteriorly)
A signet ring (flat and wide posteriorly)
What shape does the epiglottis resemble?
Leaf shapped
- petiole is the point of attachment to the thyroid cartilage
Leaf shapped
- petiole is the point of attachment to the thyroid cartilage
What are the two processes on the arytenoid cartilages?
Vocal process - anterior projection of each arytenoid; site of attachment for thyroarytenoid muscle

Muscular process - lateral projection; site of insertion of the lateral and posterior cricoarytenoid muscle
Vocal process - anterior projection of each arytenoid; site of attachment for thyroarytenoid muscle

Muscular process - lateral projection; site of insertion of the lateral and posterior cricoarytenoid muscle

The interarytenoid muscle connects the medial surfaces of these cartilages
What are the two laryngeal sesamoid cartilages?
Small cartilages above the arytenoid in the aryepiglottic fold. 
- Corniculate cartilages (aka cartilages of Santorini)
- Cuneiform cartilages (aka cartilages of Wrisberg)
Small cartilages above the arytenoid in the aryepiglottic fold.
- Corniculate cartilages (aka cartilages of Santorini)
- Cuneiform cartilages (aka cartilages of Wrisberg)
What is a triticeous cartilage?
Small elastic cartilage in thyrohyoid ligament
Not always present
Sometimes mistaken for a foreign body on soft tissue x-ray films
What are the two main laryngeal joints?
Cricoarytenoid joint - motion is primarily rotational, about a variable axis, with little gliding motion. 
- Arytenoid rotates EXternally to move vocal process
upward and outward
- Arytenoid rotates

Cricothyroid joints - primary motion is li...
Cricoarytenoid joint - motion is primarily rotational, about a variable axis, with little gliding motion.
- Arytenoid rotates EXternally to move vocal process
upward and outward
- Arytenoid rotates

Cricothyroid joints - primary motion is like a visor, or bucket handle, with minimal sliding.
The thyrohyoid membranes is pierced on each side by what vessels/nerves?
internal branch of superior laryngeal nerve and accompanying artery
internal branch of superior laryngeal nerve and accompanying artery
What is the thickened median portion of the thyrohyoid membrane called? What about lateral?
Median thyrohyoid ligament

Lateral thyrohyoid ligament
Median thyrohyoid ligament

Lateral thyrohyoid ligament
Which membrane is pierced during an emergency tracheotomy?
Cricothyroid membrane 
(the median cricothyroid ligament overlies the membrane anteriorly)
- relatively avascular
Cricothyroid membrane
(the median cricothyroid ligament overlies the membrane anteriorly)
- relatively avascular
What attaches the cricoid cartilage to the first tracheal ring?1
Cricotracheal ligament
Cricotracheal ligament
The hyoepiglottic ligament connects what?..
Posterior surface of the hyoid bone and the lingual side of the epiglottis
Posterior surface of the hyoid bone and the lingual side of the epiglottis
What is the quadrangular membrane and what are it's attachments?
Horizontal extent: from epiglottis to the arytenoids and corniculate cartilages
- extendes inferiorly to the false vocal cords
- forms upper part of the elastic membrane (the fibrous framework of the larynx)
Horizontal extent: from epiglottis to the arytenoids and corniculate cartilages
- extendes inferiorly to the false vocal cords
- forms upper part of the elastic membrane (the fibrous framework of the larynx)
What is the conus elasticus?
AKA cricovocal membrane or triangular membrane (lateral portion of the cricothyroid ligament)
- inferior attachment - superior border of the cricoid cartilage inferiorly
- superior anterior attachment - deep surface of apex of the thyroid cartil...
AKA cricovocal membrane or triangular membrane (lateral portion of the cricothyroid ligament)
- inferior attachment - superior border of the cricoid cartilage inferiorly
- superior anterior attachment - deep surface of apex of the thyroid cartilage
- superior posterior attachment - vocal process of the arytenoid cartilage
- forms lower potion of elastic membrane (below the ventricle)
What is the vocal ligament?
Free upper edge of the conus elasticus
- inserts onto the anterior thyroid cartilage as Broyle's ligament
List the depressor muscles (and innervations) of the larynx
The three muscles that are attach to the inferior hyoid:
Sternohyoid (C2, C3)
Thyrohyoid (C1)
Omohyoid (C2, C3)
The three muscles that are attach to the inferior hyoid:
Sternohyoid (C2, C3)
Thyrohyoid (C1)
Omohyoid (C2, C3)
List the elevator muscles (and innervations) of the larynx
Geniohyoid (C1)
Digastric (anterior belly V; posterior belly VII)
Mylohyoid (V)
Stylohyoid (VII)
Geniohyoid (C1)
Digastric (anterior belly V; posterior belly VII)
Mylohyoid (V)
Stylohyoid (VII)
What are the innervations of the pharyngeal constrictor muscles and where are their laryngeal attachments?
All innervated by pharyngeal plexus; all insert on posterior midline raphe. 

Superior constrictor - does not attach to the larynx
Middle constrictor - arises from hyoid and stylohyoid ligament
Inferior constrictor - arises from oblique line o...
All innervated by pharyngeal plexus; all insert on posterior midline raphe.

Superior constrictor - does not attach to the larynx
Middle constrictor - arises from hyoid and stylohyoid ligament
Inferior constrictor - arises from oblique line on thyroid cartilage.
Which muscle makes up the upper esophageal sphincter?
Cricopharyngeus muscle - continuous muscle that surrounds the esophageal inlet and attaches to each side of the cricoid cartilage.
Cricopharyngeus muscle - continuous muscle that surrounds the esophageal inlet and attaches to each side of the cricoid cartilage.
Which nerve innervates most if the intrinsic laryngial muscles?

Which is the one muscle that is not innervated by this nerve? Which nerve is it innervated by?
Recurrent laryngeal nerve

Cricothyroid muscle - supplied by the external branch of the superior laryngeal nerve
Recurrent laryngeal nerve

Cricothyroid muscle - supplied by the external branch of the superior laryngeal nerve
Thyroarytenoid muscle

What is the origin and insertion?
Origin: anterior interior surface of thyroid cartilage
Insertion: vocal process and anterior surface of the arytenoid
Origin: anterior interior surface of thyroid cartilage
Insertion: vocal process and anterior surface of the arytenoid
Thyroarytenoid muscle

What are the lateral and medial portions?
Lateral portion is just called the lateral thyroarytenoid muscle, which adducts the vocal fold. 

Medial portion is the vocalis muscle, which controls length, tension and stiffness.
Lateral portion is just called the lateral thyroarytenoid muscle, which adducts the vocal fold.

Medial portion is the vocalis muscle, which controls length, tension and stiffness.
Lateral cricoarytenoid muscle

What is the origin and insertion?
Origin: lateral cricoid arch
Insertion: muscular process of arytenoid cartilage
Origin: lateral cricoid arch
Insertion: muscular process of arytenoid cartilage
Lateral cricoarytenoid muscle

What is the action?
Pulls the muscular process anterior, which rotates the arytenoid so that the vocal process (with attached vacalis and thyroarytenoid muscles) move inward and down
Pulls the muscular process anterior, which rotates the arytenoid so that the vocal process (with attached vacalis and thyroarytenoid muscles) move inward and down
What is the only unpaired muscle in the larynx?

What is it's action?
Interarytenoid muscle (including transverse or oblique arytenoid fibers)
- connects the two arytenoid muscles = adduction
- transverse fibers assist in closing the posterior glottis
- Oblique fibers constrict the layngeal inlet
Interarytenoid muscle (including transverse or oblique arytenoid fibers)
- connects the two arytenoid muscles = adduction
- transverse fibers assist in closing the posterior glottis
- Oblique fibers constrict the layngeal inlet
Which muscle lies in the free edge of the aryepiglottic fold?
aryepiglottic muscle
aryepiglottic muscle
What is the ONLY abductor muscle of the larynx?
Posterior cricoarytenoid muscle
Posterior cricoarytenoid muscle
Posterior cricoarytenoid muscle

What is the original and insertion?
Origin: posterior cricoid lamina
Insertion: muscular process of the arytenoid cartilage
Origin: posterior cricoid lamina
Insertion: muscular process of the arytenoid cartilage
Posterior cricoarytenoid muscle

What is it's action?
Two compartments: medial (transverse) & lateral (oblique)

Actions: the only abductor in the larynx
- pulls muscular process down and back to rotate arytenoid so that vocalis process moves up and out
- Co-contracts with adductor muscles during...
Two compartments: medial (transverse) & lateral (oblique)

Actions: the only abductor in the larynx
- pulls muscular process down and back to rotate arytenoid so that vocalis process moves up and out
- Co-contracts with adductor muscles during phonation
Cricothyroid muscle

What is the origin and insertion?
Origin: anterior arch of the cricoid cartilage
Insertion: thyroid cartilage
Origin: anterior arch of the cricoid cartilage
Insertion: thyroid cartilage
Cricothyroid muscle

What is the action?
Closes the cricothyroid space and increases the distance between the anterior commissure and the posterior cricoid

Increases length and tension in vocal fold
Closes the cricothyroid space and increases the distance between the anterior commissure and the posterior cricoid

Increases length and tension in vocal fold
What are the following boundaries of the laryngeal vestibule?

Anterior:
Posterior:
Lateral:
Laryngeal vestibule: from the inlet of the larynx to the edges of the false vocal folds

Anterior: posterior surface of the epiglottis
Posterior: interarytenoid area
Lateral: false vocal folds
Laryngeal vestibule: from the inlet of the larynx to the edges of the false vocal folds

Anterior: posterior surface of the epiglottis
Posterior: interarytenoid area
Lateral: false vocal folds
What are the laryngeal ventricles?
aka ventricles of Morgagni - a deep recess between the false and true vocal folds
- saccule is a conical pouch that ascends from the anterior part of the ventricle
- numerous minor salivary glands open into the ventricle
aka ventricles of Morgagni - a deep recess between the false and true vocal folds
- saccule is a conical pouch that ascends from the anterior part of the ventricle
- numerous minor salivary glands open into the ventricle
When are the times that the glottis closes completely?
During swallowing, valsalva and cough
How would you describe the location of the pyriform fossa/sinus?
It's a pharyngeal recess within the thyroid lamina but lateral to paraglottic space
It's a pharyngeal recess within the thyroid lamina but lateral to paraglottic space
What are the three divisions of the larynx?
Supraglottis
Glottis
Subglottis
What are the borders of the supraglottis?
From the tip of the epiglottis to the beginning of squamous epithelium at the jnct between the lateral wall and the floor of the ventricle (above the true VC)
From the tip of the epiglottis to the beginning of squamous epithelium at the jnct between the lateral wall and the floor of the ventricle (above the true VC)
What are the borders of the glottis?
The true vocal folds and the posterior commissure
Membranous vocal fold - from ant commissure to vocal process of arytenoid
- composed of soft tissues: vocal ligament, muscle and the vocal cover
- from ant commisure to the vocal process of the arytenoid cartilage
- these structures vibrate to preduce the voice

Cartilaginous vocal fold - arytenoid cartilages
Posterior commissure - mucosa and the interarytenoid muscle
What are the borders of the subglottis?
from undersurface of the true vocal folds to the inferior cricoid edge
from undersurface of the true vocal folds to the inferior cricoid edge
The paraglottic space is located between which structures?
thyroid ala, conus elasticus and quadrangular membrane
thyroid ala, conus elasticus and quadrangular membrane
The pre-epiglottic space is bounded by which structures?
vallecula, thyroid cartilage, thyrohyoid membrane, and epiglottis
vallecula, thyroid cartilage, thyrohyoid membrane, and epiglottis
What kind of epithelium is there in the larynx?
Stratified squamous epithelium over vocal folds and upper vestibule

Ciliated columnar epithelium elsewhere
Stratified squamous epithelium over vocal folds and upper vestibule

Ciliated columnar epithelium elsewhere
What are the layers of the membranous vocal fold from superficial to deep?
Epithelium
Superficial lamina propria
Intermediate layer lamina propria
Deep layer lamina propria
Conus elasticus
Vocalis muscle
Epithelium
Superficial lamina propria
Intermediate layer lamina propria
Deep layer lamina propria
Conus elasticus
Vocalis muscle
What are the two main branches of vagus nerve?
Superior laryngeal nerve 

Recurrent laryngeal nerve
Superior laryngeal nerve

Recurrent laryngeal nerve
What are the two branches of the superior laryngeal nerve and what do they supply?
Internal (SENSORY) branch pierces thyrohyoid membrane and carried afferent sensation from the larynx at and above the glottis. No muscle innervation.

The external (motor) branch supplies cricothyroid muscle.
Internal (SENSORY) branch pierces thyrohyoid membrane and carried afferent sensation from the larynx at and above the glottis. No muscle innervation.

The external (motor) branch supplies cricothyroid muscle.
What does the recurrent laryngeal nerve supply?
Motor innervation to all pisilateral intrinsic laryngeal muscles except cricothyroid (external branch of SLN)
- interarytenoid muscle receives bilateral innervation
On both sides, the RLN enters the larynx near the _______________________-
cricothyroid joint
On the right side, the recurrent laryngeal loops around what? How about on the left?
Right - around subclavian artery

Left - around ligamentum arteriosum
Nonrecurrent RLN is associated with what?
Anomalous retroesophageal subclavian artery
Anomalous retroesophageal subclavian artery
Which nerve connects the SLN and RLN?
Nerve of Galen (ramus communicans) or aka laryngeal nerve
What is the arterial blood supply to the larynx?
Superior laryngeal artery - arises from the superior thyroid artery (branch of ECA)

Inferior thyroid artery - arises from the thyrocervical trunk
What is the venous blood supply from the larynx?
Superior thyroid vein - drains into internal jugular vein

Inferior thyroid vein - drains into the innominate vein
What is the lymphatic drainage of the larynx?
Supraglottic lymphatics drain to upper jugular LN, some cross over

Infraglottic lymphatics drain to pretracheal or lower jugular nodes with some crossover

Glottic lymphatic drainage is very sparse drinage, and only ipsilateral.
Why does ossification of the hyoid bone begin and finish?
Begins after birth in six centers, and finished by 2 yrs of age
Explain the mechanism of phonation
Exhaled air increases subglottic pressure to push vocal folds apart
Airflow through glottis creates negative pressure, pulling vocal folds back together (Bernoulli effect)
Myoelastic forces also pull the vocal folds back together
Cycle begins again as glottis closes
Atrophy of what part of the vocal cord may cause decreased vocal fold bulk?
Vocalis muscle - may become atrophic with aging, neuropathy and disuse
List some common causes of acute laryngitis?
URI - laryngeal inflammation usually due to cough, not direct infxn (forceful closure can result in interarytenoid edema)

Vocal abuse - due to tight closure = interarytenoid edema
GERD - due to direct irritation of posterior glottis
Often a combination of all of the above

Interarytenoid edema limits glottic closure = voice may be rough, weak or breath and increased adductor effort is required to speak.
List symptomatic and supportive treatments for acute laryngitis
Vocal hygiene - absolute silence not required
Hydration
Decongestant for nasal obstruction
Cough suppression
Mycolytic
Avoid drying antihistamines
H2 blockers or PPI's if acid reflux suspect
Steroids only for urgent need to use voice (performance). Steroids mask symptoms, therefore performers should be monitored closely to detect injury due to overuse.
What do vocal nodules present like when looking at the vocal cords?
Usually symmetric swelling or masses of the middle portion of the membranous vocal fold
Usually symmetric swelling or masses of the middle portion of the membranous vocal fold
What is the cornerstone of tx of vocal nodules?
Voice therapy (not just voice rest) - need to correct vocal habits
- occasionally early surgical removal may be recommended
- tx decisions should be based on vocal function, NOT appearance
What is the histology of a vocal fold polyp?
Out-pouching of mucosa, distended by edema and loose stroma
Out-pouching of mucosa, distended by edema and loose stroma
What is the etiology of a vocal polyp?
Unknown, sometimes due to resolving hematoma
What is the primary sx of a vocal fold polyp?
hoarseness
What is the tx of a vocal fold polyp?
Voice therapy - polyps do NOT regress, but voice may improve

Surgery - excision via direct microlaryngoscopy
What are the causes of laryngeal ulcers and granulomas?
Vocal abuse
Throat clearing
Intubation
GERD
Vocal abuse
Throat clearing
Intubation
GERD
Is surgery used for laryngeal granuloma's?
Only for symptomatic lesions which do not respond to medical therapy, or when a tumor or other pathology is suspected. Recurrence rate very high and are more recalcitrant than original lesions.
Only for symptomatic lesions which do not respond to medical therapy, or when a tumor or other pathology is suspected. Recurrence rate very high and are more recalcitrant than original lesions.
What are vocal cysts?
Vocal cysts - epithelial lined spaced; may be mucus retention or epidermoid
Vocal cysts - epithelial lined spaced; may be mucus retention or epidermoid
How are vocal cysts tx?
Direct laryngoscopy and microsurgical excision
-Hoarseness may persist or be worse, due to scarring or persistent deficiency
-Pt must be counseled about this risk and surgery must be carefully considered
What are vocal sulci? What are the two types?
Vocal sulci - depression in mucosa of vocal fold edge. Two types:
- epithelial lined pocked (Z could be a ruptured cyst)
- area of deficient lamina propria
Vocal sulci - depression in mucosa of vocal fold edge. Two types:
- epithelial lined pocked (Z could be a ruptured cyst)
- area of deficient lamina propria
How are vocal sulci treated?
Unreliable outcome of surgery

Approaches include excision, collagen or steroid injection, mucosa "slicing" technique, or mucosal elevation with submucosal grafting.
Describe etiologies of keratosis and leukoplakia of laryngeal mucosa
They are premaligantn epithelial lesions of laryngeal mucosa

Etiologies include smoking, vocal abuse, chronic laryngitis, GERD and vitamin deficiencies.
They are premaligantn epithelial lesions of laryngeal mucosa

Etiologies include smoking, vocal abuse, chronic laryngitis, GERD and vitamin deficiencies.
How do you diagnose laryngeal keratosis and leukoplakia, and what is the tx?
Diagnosis requires biopsy, but a trial of conservative measures may be indicated if malignancy is not strongly suspected.

Treatment may be conservative with cessation of smoking, antireflux therapy and voice therapy.
May also perform a direct microlaryngoscopy with excisional biopsy.
What are laryngoceles and what are the two types?
Laryngoceles are dilation of the appendix of the ventricle, filled with air or fluid. 

- Internal laryngocele - totally within the thyroid cartilage framework
- External laryngocele - extends through the thyrohyoid membrane
- May get combined...
Laryngoceles are dilation of the appendix of the ventricle, filled with air or fluid.

- Internal laryngocele - totally within the thyroid cartilage framework
- External laryngocele - extends through the thyrohyoid membrane
- May get combined lesions with dilations in both areas
List etiologies of laryngoceles
- Increased intrapharyngeal pressure (glass blowers and wind instrument players)
- Idiopathic
How do laryngocele's present?
- Hoarseness
- External laryngocele presents as swelling in the neck that may increase in size with "puffing" maneuvers
How do you treat both types of laryngoceles?
Internal laryngoceles - endoscopic marsupialization

External laryngoceles or recurrent - external approach
What are the early and late signs of laryngeal papillomatosis?
Early sign - hoarseness

Late signs - stridor and dyspnea
List some treatment options for laryngeal papillomatosis
1) Suspension microlaryngoscopy and excision using microdebrider or CO2 laser, or microsurgical instruments
2) Office-based endoscopic procedures with local anesthesia can be used
3) Cryotherapy
4) Photodynamic therapy
5) Injection of antiviral agents (cidofovir)
Why is tracheotomy typically avoided in pt's with laryngal papillomatosis?
Has been associated with subglottic and tracheal spread of lesion
What are the presentations of laryngeal chondroma?
Hoarseness, dyspnea, dysphagia, and globus sensation
More common in men than women
Most frequent site is posterior plate of the cricoid cartilage, followed by thyroid, arytenoid and epiglottis
How do you diagnose and tx laryngeal chondromas?
Dx - submucosal mass may be seen on mirror examination or office endoscopy, but is often only apparent on CT scanning

Tx - surgical excision; thyrotomy for anterior tumors, and lateral approach for other areas. Recurrence common.
What are the presentations of unilateral and bilateral laryngeal paralysis?
Sx vary greatly

Unilateral paralysis
1) No Sx - immobile vocal fold noted during routine exam
2) Most often, hoarseness due to inadequate glottal closure during phonation
3) Occasionally, aspiration during swallowing

Bilateral paralysis
1) Weak voice
2) Stidor
What is the percentage of cases of laryngeal paralysis that are idiopathic?
about 20% of cases
Does regenerated or repaired nerve restore motion to the vocal folds?
Typically no
Why does regenerating RLN still causes vocal folds to lie in the paramedian position?
Regenerating RLN preferenially reinnervates the ADductor muscles, so there is inadequate posterior cricoarytenoid muscle force for abduction
In what position doe the vocal folds lie if they are completely denervated (central or high vagus nerve injury)?
Flaccid and lies in lateral, cadaveric position
Immediately after nerve injury, in what position do the vocal folds lie?
It depends, sometimes they may be lie lateral and shift to paramedian position over a few months
List some treatment options for unilateral vocal fold paralysis
Voice therapy
Injection laryngoplasty
Type I thyroplasty (permanent medialization laryngoplasty)
Arytenoid adduction
Laryngeal reinnervation
Give a little info on the following vocal fold injectable substances:
- Teflon injection
- Gelfoam
- Autologous fat
- Commercial substances
Teflon - was the most widespread tx through the 1970's but no longer used as granulomas eventually developed
Gelfoam - temporary, off-label tx, effective for 8-10 weeks and indicated when recovery is expected within a short time
Autologous fat - harvested by liposuction or excision. Unpredictable survival--sometimes dissipates within a short time, but may survive for yrs
Commercial substances - hydroxyapatite, collagen, etc - may persist for months to years.
What is a type I thyroplasty?
Vocal fold is medialized by permanent implant placed in paraglottic space, via a window in thyroid cartilage
- usually performed under local anesthesia, so that results can be monitored during the procedure

NOT effective in pts with flaccid pa...
Vocal fold is medialized by permanent implant placed in paraglottic space, via a window in thyroid cartilage
- usually performed under local anesthesia, so that results can be monitored during the procedure

NOT effective in pts with flaccid paralysis and a large, posterior gap, or with vocal processes on different levels
Describe the arytenoid adduction procedure
Suture through muscular process is passed through anterior thyroid cartilage, and traction applied to rotate arytenoid internally. 

Indications - large glottal gap, vocal processes on different levels, aspiration. 

May be performed in combin...
Suture through muscular process is passed through anterior thyroid cartilage, and traction applied to rotate arytenoid internally.

Indications - large glottal gap, vocal processes on different levels, aspiration.

May be performed in combination with injection or thyroplasty.
Describe laryngeal reinnervation procedure for vocal fold paralysis
Most commonly, a branch of the ansa cervicalis is anastomosed to the distal recurrent laryngeal nerve. 

An alternate approach is to use a neuromuscular pedicle.  Reinnervation by either technique is reported to restore bulk and tone to the rein...
Most commonly, a branch of the ansa cervicalis is anastomosed to the distal recurrent laryngeal nerve.

An alternate approach is to use a neuromuscular pedicle. Reinnervation by either technique is reported to restore bulk and tone to the reinnervated muscles, but not functional motion. It is less effective in patients over the age of 51.
List treatments for bilateral vocal fold paralysis
1) Tracheotomy = gold standard
2) Arytenoidectomy - external or endoscopic, and total, medial or subtotal
3) Endoscopic cordotomy, cordectomy, or suture lateralization
4) Arytenoid abduction by external approach
5) Reinnervation dos not restore abductor function
6) Laryngeal "pacing" with an implantable stimulator is still experimental
What is the pathophys and etiology of spasmodic dysphonia
Spasmodic dysphonia is intermittent involuntary spasms of intrinsic laryngeal muscles during speech

Etiology is unknown
What are the two forms of spasmodic dysphonia?
Adductor form
- most frequent form
- strained and strangled voice with frequent voice breaks
- Breaks commonly occur at onset of words beginning with vowels (ie, "---eggs")

Adductor form
- About 1 in 10 pts with SD
- Whispering or breathy voice
- Voice breaks between plosive consonants and vowels (ie. "pu--pp--y")
What is the most common tx used for adductor SD?
Botulinum toxin injection
- very small amounts are injected to weaken but not paralyze the vocal fold

(may be used for adbductor SD, but less effective; toxin injected into posterior cricroarytenoid muscle)
What is the "Berke" procedure for spasmotic dysphonia?
aka Selective Laryngeal Adductor Denervation-Reinnervation (SLAD-R), described by Dr. Berke
- transects adductor branches of the RLNs and reinnervates with branches of the ansa cervicalis
Does a cuffed trach tube prevent aspiration?
No, but allows for suctioning and may decrease amount of material reaching lungs
List some procedures aimed at pts with dysphagia with severe aspiration
1) Tracheotomy
2) Surgical separation of the larynx and trachea and creation of a tracheostomy
3) Epiglottic flap to arytenoids
4) Lindeman's tracheoesophageal diversion procedure with proximal trachea to esophagus anastomosis and creation of a distal permanent tracheostoma.
5) Suturing vocal folds together via a laryngofissue. Theoretically a reversible procedure.
6) Total laryngectomy
What is the dx? 

What is the tx?
What is the dx?

What is the tx?
Laryngeal candidasis
- Tx - need systemic antifungal tx. Topical and swallowed nystatin is ineffective
- withhold steroids (especially if inhaled)
Pt has dyspnea. What is the dx?
Pt has dyspnea. What is the dx?
Epiglottitis (infectious inflammation and edema of the supraglottis)
List the possible infectious etiologies of croup
Parainfluenza virus types 1 to 4
H. influenza
Streptococci
Staphylococci
Pneumococci
Pt has dyspnea. What is the dx?
Pt has dyspnea. What is the dx?
Croup - "steeple" sign
What are some agents causing bacterial tracheitis?

What are sx of bacterial tracheitis?
Staph & Strep

High fever, stridor and sx of severe croup
What does the tracheal look like on its visualization in a pt with bacterial tracheitis?
Purulent racheitis, with obstruction due to edema and sloughed necrotic mucosa and mucus casts
Purulent racheitis, with obstruction due to edema and sloughed necrotic mucosa and mucus casts
What is the incidence of laryngeal involvement in pts with Hansen's disease
Hansen's dz = Leprosy (Mycobacterium leprae)
- Involves larynx in 10% of cases
Which mycotic infections affect the larynx?
Blastomycosis (Blastomyces dermatitidis) and Histoplasmosis (Histoplasma capsulatum)
- tx both with Amphotericin B
Pt has granulomas through out the body and are also seen as pale submucosal masses in the epiglottis and larynx. What is the likely diagnosis?
Sarcoidosis (dx by biopsy)
How do you diagnose RA as the cause of laryngeal pathology?
Rheumatoid arthritis may cause inflammatory fixation of the cricoarytenoid join and/or inflammatory nodules on the volca fold.

Serology - elevated ESR, rheumatoid factor, decreased complement levels and abnormal lupus panel

Can get a high-resolution CT scan demonstrating erosion of join and soft tissue swelling
How is the larynx affected in pt's with Wegener's granulomatosis?
WG affects primarily the lung and kidneys but larynx is affected up to 25% of the time. 

Exophytic granulation tissue that often progresses to subglottic stenosis.
- biopsy will show necrotizing granulomas and capillary thrombosis
- ANA may b...
WG affects primarily the lung and kidneys but larynx is affected up to 25% of the time.

Exophytic granulation tissue that often progresses to subglottic stenosis.
- biopsy will show necrotizing granulomas and capillary thrombosis
- ANA may be positive, but cANCA is more sensitive
What are the tx options for relapsing polychondritis?
Medical - steroids, dapsone, azathioprine, cyclophosphamide, cyclosporine, penicillimine, and plasma exchange

Surgery - is ineffective; airway dz can progress to death from PNA or obstructive respiratory failure
What is the tx for pemphigus and pemphigoid?
Dapsone, steroids and azathiaprine
What is the typical head & neck presentation of pemphigus and pemphigoid?
Mouth and throat pain and hoarseness

Both disorders usually begin with mouth ulcers that can spread as far caudal as the larynx, but do not involve the subglottis or trachea
What is the head & neck presentation of amyloidosis?
Hoarseness, stridor, globus and dysphagus

Diagnosis is based on laryngeal examination showing waxy lesions that may be gray or orange, typically on the epiglottis, but sometimes glottic or subglottic.
Hoarseness, stridor, globus and dysphagus

Diagnosis is based on laryngeal examination showing waxy lesions that may be gray or orange, typically on the epiglottis, but sometimes glottic or subglottic.
What will the biopsy of a lesion suspected to be due to amyloidosis look like?
Histology stained with hematoxylin and eosin is nonspecific. 

Specimens should be processed with Congo red stain and viewed under polarized light to show apple green birefringence
Histology stained with hematoxylin and eosin is nonspecific.

Specimens should be processed with Congo red stain and viewed under polarized light to show apple green birefringence
What is the tx of laryngeal amyloidosis?
Endoscopic excision or open surgery to remove or debulk symptomatic lesions

Total removal often impossible with frequent recurrence
Tracheotomy may be required
How do you manage acute airway distress secondary to blunt laryngeal trauma?
1) Proceed directly to OR for trach with local anesthesia, followed by direct laryngoscopy under general anesthesia to assess injury
2) Orotracheal intubation not erecomended due to laryngeal distortion and tube may create a false passage
How is blunt trauma to the larynx be managed surgically?
A midline thyrotomy is used to expose laryngeal mucosa. All lacerations should be carefully sutured. Local flaps or free mucosal grafts may be used to close defects.

If an arytenoid cartilage is completely avulsed and displaced, it is better to remove it than attempt to reposition it.
How are laryngeal cartilage fractures managed?
Should be reduced and immobilized with plates if necessary. 
Laryngeal stents may be used to add stability, but can stimulate granulation tissue.
Should be reduced and immobilized with plates if necessary.
Laryngeal stents may be used to add stability, but can stimulate granulation tissue.
What are the etiologies of laryngeal/tracheal stenosis?
Intubation
External injury
Systemic disease
Acid reflux
Idiopathic
What is the most common cause of neonatal stridor?
Laryngomalacia - supraglottis is flaccid, and epiglottis or interarytenoid tissue collapse during inspiration to obstruct the airway
Laryngomalacia - supraglottis is flaccid, and epiglottis or interarytenoid tissue collapse during inspiration to obstruct the airway
What is the etiology of laryngomalacia?
Unknown, probably neurologic or structural immaturity
What are the three types of laryngomalacia?
Type 1 - foreshortened or tight aryepiglottic folds
Type 2 - redundant tissue in the supraglottic
Type 3 - posterior epiglottic collapse due to underlying neuromuscular disorders
Type 1 - foreshortened or tight aryepiglottic folds
Type 2 - redundant tissue in the supraglottic
Type 3 - posterior epiglottic collapse due to underlying neuromuscular disorders
What is the typical presentation of laryngomalacia?
Stridor is noted soon after birth
Breathing is better in prone position rather than supine
How do you diagnose laryngomalacia?
Flexibile endoscopy in the office
"omega" shaped epiglottis
Epiglottis falls backwards during inspiration
What is the typical tx for laryngomalacia?
Usually obs and assurance that this will resolve by 12-16 months
Endoscopic epiglottoplasty for severe stridor or failure to thrive
Trachotomy may be required
What is the second most common cause of newborn stridor?
Laryngeal paralysis
List the causes of laryngeal paralysis in a newborn
1) Idiopathic
2) Birth trauma
3) Cardiomegaly
4) Arnold-Chiari malformation
5) Ligation of persistent ductus arteriosis

(usually unilateral, but may be bilateral)
What is the tx of a laryngeal hemangioma?
Natural history is expansion for several months followed by involution, so may just observe.
- Systemic steroids and racemic epinephrine for acute stridor
- Systemic propranolol can result in dramatic involution
- CO2 laser excision, external excision, or tracheotomy if obstruction does not respond to propranolol.
What are laryngeal webs and atresia?
A congenital band over part (web) and all (atresia) of the glottis
A congenital band over part (web) and all (atresia) of the glottis
What is the tx for laryngeal webs and atresia?
Tracheotomy for relief of airway obstruction
Web is best corrected when child is larger and anatomy is more distinct
Successful division of web may not improve the voice
What is the tx for congenital subglottic stenosis?
Tx - tracheotomy, cricoid split or laryngotracheal reconstruction

(may be congenital, or secondary to intubation)
Tx - tracheotomy, cricoid split or laryngotracheal reconstruction

(may be congenital, or secondary to intubation)
What is the cause of laryngeal clefts?
Rare anomaly caused by incomplete fusion of the laryngotracheal septum
Rare anomaly caused by incomplete fusion of the laryngotracheal septum
What is the presentation of laryngeal clefts?
Cyanosis with feeding, stridor, recurrent pneumonia. Severity due to extent of cleft.
What is the tx of laryngeal clefts?
Some can be observed and will eventually improve, others require repair by endoscopic or open rapair
When should the first trach change be performed, and why not done it earlier?
Typically no earlier than day 5. Study of 46 institutions demonstrated mean first trach change at 5.3 days. New study recommends 7-14 days.

Not done earlier to prevent reentry into false passage, and there's really no need to change it earlier.
List the immediate complications of tracheotomy
Bleeding
Pneumothorax
Pneumomediastinum
Subcutaneous emphysema
Dislodged or obstructed tube
False passage with tube outside trachea
Postobstructive pulmonary edema
Apnea due to loss of hypoxic drive
Tube too short or inappropriate shape (esp in morbidly obese pts)
List the delayed complications of tracheotomy
Granulation tissue
Stomal infection
Subglottic or tracheal stenosis
Tracheomalacia
Tracheoesophageal fistula
Displacement of tube
Tracheoinnominate fistula
Persisting tracheocutaneous fistula after decannulation