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17 Cards in this Set
- Front
- Back
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which R can be stim to increases renin
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beta 1 as well as glucagon
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osmotic diuretic?
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Mannitol
increase renal tubular fluid osmolarity PCT, Descending thin and CD |
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Mannitol Use and SE?
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used for increased intracranial P
Contraindicated? CHF and Anuria (trouble will urine amount) |
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Loop diuretics?
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Furosemide and Ethycrynic Acid
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Furosemide and Ethycrynic Acid MOA
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onhibits Na/K/2Cl in thick Asc
stim PGE (inhib by NSAIDS!!!!!!) so don't use loop with NSAIDS USE- Acute Pulmonary edema ethycrynic no sulfa in it |
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Furosemide and Ethycrynic Acid SE
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OTOTOXICITY, hypokalemia, dehydration, sulfa allergy, interstitial nephritis gout
most diuretics lead to hypoK so this is why we have a category to K spare |
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Gout 1st line
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Acute-
indomethacin 2nd line colchicine renal failure- steroids chronic-allopurinol and probenicid |
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Carbonic Anhydrase Inhibitor?
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causes acidosis=acetazolamide
makes you pee out bicarb (PCT usia;;y absorbs Bicarb so opposite) Uses acute mountain syndrome and for metabolic alkalosis |
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Hydrochlorothiazide
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Na/Cl ingib reabs in DCT
LESS STONES use- HTN!!! cHF, calcium stones!!! Nephrogenic DI (diuresis is very dilute b/c nephron not responding to ADH so must make urine more concentrated so pt will actually pee less) SE HYPERGLUC and hypokalemiametabolic alkalosis and hyponatremia hypo and hypernatremic you are BOTH more likely to depolarize b/c potassium can depot |
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K sparing?
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spironolactone
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spironolactone
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competitive antagonist of aldosterone R in the Collecting tubule
Use- HIRUSTISM, Conn syndrom ,waterhouse freidricson-->hyperaldosteronism, CHF |
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spironolactone SE
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HYPERkalemia.....anytime you mess with potassium arrhythmias!!!!
gynecomastia Anti-Androgen Effects |
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Triamterene and Amiloride
Se hyperkalemia |
K sparing diuretics
block Na channels in cortical collecting tubule Use hyperaldosteronism and CHF and K depletion |
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ACEI
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-pril
prevents Bradykinin activation! DECREASE MORTALITY IN CHF decreases AT2- so no more tensing of efferent arteriole Use HTN, CHF, renal dz bc DM Give for HTN in DM!!!!!! |
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ACEI SE
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COUGH, ANGIOEDEMA, teratogen (renal abn), hypotension, hyperkalemia, INC CREATININE (DECR GFR)
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Angiotensin R blocker ARB
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sartans
blocks ATII R Do not increase kallikrein...no cough also cause angioedema except Candesartan b/c she is so sweet USE HTN, CHF, Renal Dz bc DM |
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angioedema reason
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C1 esterase def or ACEI and some ARB
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