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26 Cards in this Set
- Front
- Back
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Monophasic
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constant E & P
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Bi-phasic
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constant E, E+P
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Triphasic
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constant E, increasing E or P, increasing P
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Norgestrel AR/MR activity
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High AR
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Levonorgestrel AR/MR activity
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High AR
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Desogestrel AR/MR activity
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Low AR, No ER, better HDL
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Norgestimate AR/MR activity
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Little ER, Low AR
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Norithidrone AR/MR activity
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PR > AR
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Drospirenone AR/MR activity
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Anti AR
Anti MR |
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E + P Therapy Positive Effects
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Decreases Ovarian/Endometrial Cancer
Decreases Ovarian Cysts Decreases Benign Fibrocystic Dz |
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E + P Therapy Negative SE
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Increases HTN (angiotensin inc.)
Increases Thrombus (clotting factors inc.) Increases Gall Stones (inc. bile cholesterol) & period SE |
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Drugs Affecting E
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Hepatically: Carbamazepine, Phenytoin, Barbituates
Conjugation: Penicillin, Tetracycline |
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Drugs E Affects
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inc. Vit K --> Must Inc Warfarin Dose
Cyclosporine, Glucocorticoids, Imipramine Inc. Hepatotox of Dantrolene |
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MOA of Progestin Only Contraceptives
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Increase Thickness of Mucus
Blunt LH Surge Thin atropic endometrium |
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Pregnanes
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(methoxyprogesterone acetate) MPA
megestrol acetate |
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Estranes
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19-nortestosterone
norethiodrone |
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Gonanes
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levonorgesterel
norgestrel 19-norgestrel norestimate |
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Anti-Progestins
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Mifepristone (also inhibits GR)
Ulipristal (Selective Progesterone Receptor Mediator - SRP) Onaprostone |
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Horomone Replacement Tx Oral & Transdermal
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Oral - Premarin (Equine) /Prempro (Equine + Progest.)
Transdermal - Estradiol All have risk of thrombus due to estrogen |
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Risk/Benefits of Hormone Replacement Tx
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Risk - Increase Heart Attack/CAD, Embolism, Breast Cancer (more to do w Progest), Dementia
Benefit - Decrease Osteoperosis, Colorectal Cancer & Hot Flashes/Atrophic Vaginitis |
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MOA of Estrogen Embolism
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decrease antithrombin III --> increased plasminogen activator inhibitor protein 1 (PAI-1)
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Tamoxifen Tissue Specific Ag/Antag
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Agonist @ Uterus & Bone
Antag @ Breast |
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Raloxifene Tissue Specific Ag/Antag
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Agonist @ Bone
Antag @ Uterus & Breast |
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Toremifene
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SERM used for treatment of Breast Cancer in postmenopausal women
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Estrogen Antagonist _____ used for... & indication
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Clomiphene used to induce ovulation in amenorrhea, PCOS & anovulatory cycles.
Weak estrogen effects on endometrium |
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ER-alpha location
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highest in reproductive tract & CV system
same affinity to estradiol as ER-beta |
