Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/26

Click to flip

26 Cards in this Set

  • Front
  • Back
Monophasic
constant E & P
Bi-phasic
constant E, E+P
Triphasic
constant E, increasing E or P, increasing P
Norgestrel AR/MR activity
High AR
Levonorgestrel AR/MR activity
High AR
Desogestrel AR/MR activity
Low AR, No ER, better HDL
Norgestimate AR/MR activity
Little ER, Low AR
Norithidrone AR/MR activity
PR > AR
Drospirenone AR/MR activity
Anti AR
Anti MR
E + P Therapy Positive Effects
Decreases Ovarian/Endometrial Cancer
Decreases Ovarian Cysts
Decreases Benign Fibrocystic Dz
E + P Therapy Negative SE
Increases HTN (angiotensin inc.)
Increases Thrombus (clotting factors inc.)
Increases Gall Stones (inc. bile cholesterol)

& period SE
Drugs Affecting E
Hepatically: Carbamazepine, Phenytoin, Barbituates

Conjugation: Penicillin, Tetracycline
Drugs E Affects
inc. Vit K --> Must Inc Warfarin Dose
Cyclosporine, Glucocorticoids, Imipramine
Inc. Hepatotox of Dantrolene
MOA of Progestin Only Contraceptives
Increase Thickness of Mucus
Blunt LH Surge
Thin atropic endometrium
Pregnanes
(methoxyprogesterone acetate) MPA
megestrol acetate
Estranes
19-nortestosterone
norethiodrone
Gonanes
levonorgesterel
norgestrel
19-norgestrel
norestimate
Anti-Progestins
Mifepristone (also inhibits GR)
Ulipristal (Selective Progesterone Receptor Mediator - SRP)
Onaprostone
Horomone Replacement Tx Oral & Transdermal
Oral - Premarin (Equine) /Prempro (Equine + Progest.)

Transdermal - Estradiol

All have risk of thrombus due to estrogen
Risk/Benefits of Hormone Replacement Tx
Risk - Increase Heart Attack/CAD, Embolism, Breast Cancer (more to do w Progest), Dementia

Benefit - Decrease Osteoperosis, Colorectal Cancer & Hot Flashes/Atrophic Vaginitis
MOA of Estrogen Embolism
decrease antithrombin III --> increased plasminogen activator inhibitor protein 1 (PAI-1)
Tamoxifen Tissue Specific Ag/Antag
Agonist @ Uterus & Bone

Antag @ Breast
Raloxifene Tissue Specific Ag/Antag
Agonist @ Bone

Antag @ Uterus & Breast
Toremifene
SERM used for treatment of Breast Cancer in postmenopausal women
Estrogen Antagonist _____ used for... & indication
Clomiphene used to induce ovulation in amenorrhea, PCOS & anovulatory cycles.

Weak estrogen effects on endometrium
ER-alpha location
highest in reproductive tract & CV system

same affinity to estradiol as ER-beta