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10 Cards in this Set
- Front
- Back
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1) Clinical: two patients who weigh the same and have normal renal and hepatic
function are given a single dose of a drug old patient Cpo = 14 mcg/ml young patient Cpo = 10 mcg/ml Why is Cpo different? |
A: the older patient has a smaller Vd, or the younger patient has a larger Vd
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A patient tx w methotrexate develops bone marrow depression. How to tx?
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: “leucovorin rescue” = tx w leucovorin (folinic acid) to reverse bone marrow
depression. Normal cells can take up leucovorin, but tumor cells cannot, so leucovorin rescues normal cells but not tumor cells |
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A patient is given a dose of 100 mg and the Cp is 10 mg/L. What dose
would you have to give to achieve a Cp of 30 mg/L? |
300 mg
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patient tx w beta-blocker for angina d/c drug increased cardiac -receptor
stimulation increased O2 demand angina and MI What happened? |
beta-blocker withdrawal syndrome
(tachycardia, palpitations, tremor, chest pain) |
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patient with hyperthyroidism tx
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with propranolol to tachycardia and tremor and
prevent the peripheral conversion of T4 to T3, |
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type I diabetic patient treated with glaucoma drug which causes hypoglycemia. Which
drug? |
timolol
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MOA in tx of CHF
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increase CO by decreasing preload and afterload; reverses cardiac remodeling caused by angiotensin II (ang II)
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HT patient with DM tx
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tx w ACEI to BP and proteinuria (protects kidneys)
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linical Pat w DM & microalbuminuria - Tx
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ACEI or -ARB to dec. proteinuria
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: patient tx with OCP containing estrogen + norethindrone develops hirsutism - why? how to tx?
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hirsutism results from androgenic effects of the progestin norethindrone which is a derivative of 19-nortestosterone; tx with spironolactone
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