Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/20

Click to flip

20 Cards in this Set

  • Front
  • Back
Five key features of neurotransmitter fnction represent potential targets of pharmacologic therapy
Synthesis
storage
release
activation of receptors
termination of action
Primary neurotransmitter for cardiac and smooth muscle, gland cells and nerve terminals
Acetylcholine at muscarinic receptors
Primary neurotransmitter at sympathetic sweat glands
Acetylcholine at muscarinic receptor
Primary sympathetic neurotransmitter for cardiac and smooth muscle, gland cells and nerve terminals
Norepinephrine at alpha and beta receptors
Primary sympathetic neurotransmitter for renal vascular smooth muscle
Dopamine at D1 receptors
Primary somatic neurotransmitter at skeletal muscle
Acetylcholine at nicotinic receptors
Vesicles are initially synthesized in the
neuron soma and transported to the terminal
Acetylcholine is synthesized in the cytoplasm from Acetyl-CoA and choline through this enzyme
Choline acetyltransferase

ChAT
Choline can be blocked from being transported into the cell by
hemicholiniums
Acetylcholine transport is blocked by
vesamicol
Acetylcholine vesicle release is blocked by
Botulinum toxin
Rate-limiting step in catecholamine transmitter synthesis
Conversion of tyrosine to dopa
Rate-limiting step in catecholamine synthesis can be inhibited by
metyrosine
Depletion of catecholamine stores results from
Reserpine
Reuptake of norepinephrine is inhibited by
Cocaine and TCA's
Indirectly acting sympathomimetics
Tyramine and amphetamines

Poor agonists but are taken up by reuptake and may displace NE from storage vesicles
reuptake into the nerve terminal
uptake 1
uptake 2
reuptake into perisynaptic glia or smooth muscle
Trophotropic
"rest and digest"

Parasympathetic
Ergotropic
"fight or flight"

Sympathetic