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9 Cards in this Set
- Front
- Back
Describe Cole Hypothesis for Bronchiectasis
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1. Environmental/Microbial Insult
2. Genetic Predisposition: defect in host defense 3. LRTI 4. Bronchial Inflammation 5. LRT damage ---back to 3-- -results in progressive lung Dx |
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Name for layer between Mucus and Ciliated Cells
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Periciliary Fluid Layer
--watery fluid in that bathes cilia, what they beat in |
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With Brochiectasis, what can happen to following cells
Cilia: Goblet Cells: Submucosal Glands: |
Ciliated Cell Metaplasia: become squamous or columnar/loose cilia
Goblet Cells: hyperplasia Submuc Cells: hypertrophy |
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In Bronchiectasis, where is inflammation most prominent?
--Effect on other airways? |
In Small Airways--bronchioles
-inflm mediators spill over into larger; effect Elastin w/ -proteases -inflam can also spill over into interstitium appearing as Pneumonitis |
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Test Question:
Necessity for Bronchiectasis (2) |
Host Immune Problem
Recurrence of Bronchial Obstruction |
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name and describe the 3 main types of of "reid" dilations
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Tubular: smooth dilation
Varicose: dilated with multiple indentations Cystic: dilated bronchi end in blind sacs |
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What is typical result of FVC on bronchiectasis if severe
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Decreased FVC (restricted dx)
-more often, as it is an obstructive, FVC follows obstructive pattern |
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What is current Gold Standard for bronchiectasis
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High Res CT
--see airway dilation lack of tapering of these vessels bronchial wall thickeniing mucopurulent plugs |
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What is ABPA
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Allergic Brochno Pulmonary Aspergillosus
--common with bronchiectasis ---elevated IgE and anti-Aspergillus ABs -not actual infxn of aspergillius, buta hyperreactivity to it |