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80 Cards in this Set

  • Front
  • Back

What drugs are Ototoxic... Auditory?

Loops (Ethacrynic Acid > Furosemide)
VANCOMYCIN
Macrolides
Cisplatin

What drugs are Ototoxic... Vestibular?

Minocycline

What drugs are Ototoxic Auditory and Vestibular?

Aminoglycosides

What drugs are Ototoxic causing Tinnitus?

Quinidine/Quinine (cinchonism)
ASA (salicylism)

What drugs are nephrotoxic?

Vancomycin
Aminoglycosides
Amphothericin B
Foscarnet (hypercalcemia)
Cisplatin (minimized w/ Amifestine)
Cyclosporine

What drug causes causes SIADH?

Carbamazepine
Chlorpropamide

What drug causes Nephrogenic DI?

Lithium
Demeclocycline

What drug causes hemorrhagic cystitis?

Cylcophosphamide

How do you prevent hemorrhagic cystitis w/ cyclophosphamide?

MESNA

How do you minimize nephrotoxicity from Cisplatin?

Amifostine

What are the hepatotoxic drugs?

AMIODARONE
STATINS
VALPROIC ACID (hepatitis)
Felbamate
Tolcapone
TETRACYCLINE (in pregnancy)
RIPE TB therapy (Rifampin, Isoniazid, Pyrazinamide)
ACETAMINOPHEN

What do you give to OD w/ ACETAMINOPHEN?

Acetylcysteine

What drugs cause Blood dyscrasias?

Carbamazepine

What drug causes Aplastic Anemia?

Felbamate

What drug causes agranulocytosis?

Clozapine

What drug causes aplastic anemia and is dose dependent and dose independent?

Chloramphenicol

What HIV medication causes Blood dyscrasias (anemia/bone marrow suppresion)?

Zidovudine

What anticoagulant produces thrombocytopenia?

Heparin

What drug causes thrombotic thromocytopenia, purpura or TPP?

Ticlopidine

Most Cancer chemotherapeutic drugs cause?

Blood Dyscrasias

What drugs cause pancreatitis?

Valproic Acid
Didanosine/Zalcitabine
Sulindac
Asparaginase

What drug used for seizures causes pancreatitis?

Valproic Acid

What drug used for HIV cause pancreatitis?

Didanosine
Zalcitabine

What NSAID causes pancreatitis?

Sulindac

What drug used for ALL causes pancreatitis?

Asparaginase

What drugs produce gingival hyperplasia?

Phenytoin
Nifedipine
Cyclosporine

What drugs cause SLE in SLOW acetylators?

Hydralazine
Isoniazid
Procainamide

Drugs w/ problems with Atypical Pseudocholinesterase?

Succinylcholine (prolongs the activity)

What drug causes malignant hyperthermia?

Halothane/SUX

What drug causes Hemolytic Anemia in G6PD deficiency?

Sulfonamide
Primaquine
Quinidine

What drugs cause disulfiram like reaction?

Metronidazole
Chlorpropamide
Griseofulvin
Cefamandole
Cefotetan
Cefoperazone

What drug (combination) causes Serotonin Sx?

MAOIs, TCAs, SSRIs, Meperidine

What drug causes acute hypertensive crisis?

Non-Selective MAOIs + Tyramine

What are the non-selective MAOIs?

Phenelzine
Trancylpromine

What contains Tyramine?

Aged Cheese
Red Wine

What DDI (drug-drug interaction) causes decrease in B.P. and possible death?

Sildenafil + Nitroglycerin

What two drugs in anti-cancer therapy you should never mix?

6-MP (Azathioprine) + Allopurinol
precipitate gout

DOC for Borrelia?

Doxycicline

DOC for Ricketssia?

Doxycycline

DOC for T. pallidum?

Penicillin G

DOC for gonorrhea?

Ceftriaxone
"Floxacins"

DOC for Atypicals (Chlamydia, Mycoplasma)?

Doxycicline or
Macrolide

DOC listeria?

Ampicillin

DOC Legionella?

Macrolide

DOC Step (Group A)?

Pen G [V]

DOC C. difficile?

Metronidazole
or Vancomycin

DOC enterococcus?

Penicillin + AG (Aminoglucoside)

DOC P. areuginosa?

Ticarcillin + AG

DOC for T. pallidum but penicillin allergy?

Doxycicline

DOC N. gonorreah but Penicillin Allergy?

Floxacin

DOC for Listeria but penicillin allergy?

TMP-SMX

DOC Strep (Group A) but penicillin allergy?

Macrolide

DOC enterococcus but penicillin allergy?

Vacomycin + AG

DOC P. areuginosa but penicillin allergy?

Aztreonam

DOC Borrelia in Pregnancy or Child?

Amoxicillin

DOC Ricketssia in Pregnancy or Child?

Chloramphenicol

DOC N. gonorrhea in Pregnancy or Child?

Ceftriaxone

DOC atypicals [chlamydia, Mycoplasma] in Pregnancy or Child?

Macrolide

DOC P. areuginosa w penicillin allergy?

Aztreonam, AG, Floxacin

DOC for Borelia for a prenant woman?

Amoxicillin

DOC N. gonorrhea for a prenant woman?

Ceftriaxone

DOC Atypicals [Chlamydia, Mycoplasma] for a prenant woman?

Macrolide

DOC for Borrelia in Children?

Amoxicillin

DOC N. gonorrhea in Children?

Ceftriaxone

DOC Atypicals in Children?

Macrolides

What is the Serotonin Sx?

Hyperthermia
Rigidity
Autonomic Instability
Myoclonus

Kind of like when having sex!!!

What causes Serotonin Sx in w/ Meperidine?

Combination w/ MAOIs, TCAs
but it is a metabolite called normeperidine that acts like SSRI

How do protease inhibitors work?

Inhibit Aspartate Protease

Name two protein inhibitors?

Indinavir
RitonAVIR

gp120
gp41

What happens to Uric Acid at high does Aspirin?

UA stays in the lumen and is peed out = uricosuric

What happens to Uric acid w/ low dose Aspirin?

Transport of UA (Uric Acid) is blocked from the blood to the lumen so it causes hyperuricemia
Aspirin (low dose) blocks secretion of Uric Acid

What drug protects patient from nephrotoxicity taking cisplatin?

Amifostine

What drug prevents cardiotoxicity w/ Doxorubicin?

Dexrazoxane

What drug prevents toxicity to epithelial, GI and bone marrow in Methotrexate high dose anti-cancer tx?

Leucovorin
restores purines

Where does Aspirin work?

COX-1
Cycloxygenase 1

Where does abcximab work?

GP IIB/IIIA receptor on platelets. Can't join together

Where does ticlopidine work? (Clopidrogel)

Blocks ADP release

Where does propilthioracil and Methimazole work?

Peroxidase in thyroid synthessis

Where does Iodide (high dose) work?

blocks release of proteolytic T3 ---> T4

Where does Propilthioracil and Propanolol work?

inhibit deiodinase (liver) conversion of T4 to T3