Kaplan Powerpoint Pharm Review Usmle Step 1

Front 1

What drugs are Ototoxic... Auditory?

Back 1

Loops (Ethacrynic Acid > Furosemide)
VANCOMYCIN
Macrolides
Cisplatin

Front 2

What drugs are Ototoxic... Vestibular?

Back 2

Minocycline

Front 3

What drugs are Ototoxic Auditory and Vestibular?

Back 3

Aminoglycosides

Front 4

What drugs are Ototoxic causing Tinnitus?

Back 4

Quinidine/Quinine (cinchonism)
ASA (salicylism)

Front 5

What drugs are nephrotoxic?

Back 5

Vancomycin
Aminoglycosides
Amphothericin B
Foscarnet (hypercalcemia)
Cisplatin (minimized w/ Amifestine)
Cyclosporine

Front 6

What drug causes causes SIADH?

Back 6

Carbamazepine
Chlorpropamide

Front 7

What drug causes Nephrogenic DI?

Back 7

Lithium
Demeclocycline

Front 8

What drug causes hemorrhagic cystitis?

Back 8

Cylcophosphamide

Front 9

How do you prevent hemorrhagic cystitis w/ cyclophosphamide?

Back 9

MESNA

Front 10

How do you minimize nephrotoxicity from Cisplatin?

Back 10

Amifostine

Front 11

What are the hepatotoxic drugs?

Back 11

AMIODARONE
STATINS
VALPROIC ACID (hepatitis)
Felbamate
Tolcapone
TETRACYCLINE (in pregnancy)
RIPE TB therapy (Rifampin, Isoniazid, Pyrazinamide)
ACETAMINOPHEN

Front 12

What do you give to OD w/ ACETAMINOPHEN?

Back 12

Acetylcysteine

Front 13

What drugs cause Blood dyscrasias?

Back 13

Carbamazepine

Front 14

What drug causes Aplastic Anemia?

Back 14

Felbamate

Front 15

What drug causes agranulocytosis?

Back 15

Clozapine

Front 16

What drug causes aplastic anemia and is dose dependent and dose independent?

Back 16

Chloramphenicol

Front 17

What HIV medication causes Blood dyscrasias (anemia/bone marrow suppresion)?

Back 17

Zidovudine

Front 18

What anticoagulant produces thrombocytopenia?

Back 18

Heparin

Front 19

What drug causes thrombotic thromocytopenia, purpura or TPP?

Back 19

Ticlopidine

Front 20

Most Cancer chemotherapeutic drugs cause?

Back 20

Blood Dyscrasias

Front 21

What drugs cause pancreatitis?

Back 21

Valproic Acid
Didanosine/Zalcitabine
Sulindac
Asparaginase

Front 22

What drug used for seizures causes pancreatitis?

Back 22

Valproic Acid

Front 23

What drug used for HIV cause pancreatitis?

Back 23

Didanosine
Zalcitabine

Front 24

What NSAID causes pancreatitis?

Back 24

Sulindac

Front 25

What drug used for ALL causes pancreatitis?

Back 25

Asparaginase

Front 26

What drugs produce gingival hyperplasia?

Back 26

Phenytoin
Nifedipine
Cyclosporine

Front 27

What drugs cause SLE in SLOW acetylators?

Back 27

Hydralazine
Isoniazid
Procainamide

Front 28

Drugs w/ problems with Atypical Pseudocholinesterase?

Back 28

Succinylcholine (prolongs the activity)

Front 29

What drug causes malignant hyperthermia?

Back 29

Halothane/SUX

Front 30

What drug causes Hemolytic Anemia in G6PD deficiency?

Back 30

Sulfonamide
Primaquine
Quinidine

Front 31

What drugs cause disulfiram like reaction?

Back 31

Metronidazole
Chlorpropamide
Griseofulvin
Cefamandole
Cefotetan
Cefoperazone

Front 32

What drug (combination) causes Serotonin Sx?

Back 32

MAOIs, TCAs, SSRIs, Meperidine

Front 33

What drug causes acute hypertensive crisis?

Back 33

Non-Selective MAOIs + Tyramine

Front 34

What are the non-selective MAOIs?

Back 34

Phenelzine
Trancylpromine

Front 35

What contains Tyramine?

Back 35

Aged Cheese
Red Wine

Front 36

What DDI (drug-drug interaction) causes decrease in B.P. and possible death?

Back 36

Sildenafil + Nitroglycerin

Front 37

What two drugs in anti-cancer therapy you should never mix?

Back 37

6-MP (Azathioprine) + Allopurinol
precipitate gout

Front 38

DOC for Borrelia?

Back 38

Doxycicline

Front 39

DOC for Ricketssia?

Back 39

Doxycycline

Front 40

DOC for T. pallidum?

Back 40

Penicillin G

Front 41

DOC for gonorrhea?

Back 41

Ceftriaxone
"Floxacins"

Front 42

DOC for Atypicals (Chlamydia, Mycoplasma)?

Back 42

Doxycicline or
Macrolide

Front 43

DOC listeria?

Back 43

Ampicillin

Front 44

DOC Legionella?

Back 44

Macrolide

Front 45

DOC Step (Group A)?

Back 45

Pen G [V]

Front 46

DOC C. difficile?

Back 46

Metronidazole
or Vancomycin

Front 47

DOC enterococcus?

Back 47

Penicillin + AG (Aminoglucoside)

Front 48

DOC P. areuginosa?

Back 48

Ticarcillin + AG

Front 49

DOC for T. pallidum but penicillin allergy?

Back 49

Doxycicline

Front 50

DOC N. gonorreah but Penicillin Allergy?

Back 50

Floxacin

Front 51

DOC for Listeria but penicillin allergy?

Back 51

TMP-SMX

Front 52

DOC Strep (Group A) but penicillin allergy?

Back 52

Macrolide

Front 53

DOC enterococcus but penicillin allergy?

Back 53

Vacomycin + AG

Front 54

DOC P. areuginosa but penicillin allergy?

Back 54

Aztreonam

Front 55

DOC Borrelia in Pregnancy or Child?

Back 55

Amoxicillin

Front 56

DOC Ricketssia in Pregnancy or Child?

Back 56

Chloramphenicol

Front 57

DOC N. gonorrhea in Pregnancy or Child?

Back 57

Ceftriaxone

Front 58

DOC atypicals [chlamydia, Mycoplasma] in Pregnancy or Child?

Back 58

Macrolide

Front 59

DOC P. areuginosa w penicillin allergy?

Back 59

Aztreonam, AG, Floxacin

Front 60

DOC for Borelia for a prenant woman?

Back 60

Amoxicillin

Front 61

DOC N. gonorrhea for a prenant woman?

Back 61

Ceftriaxone

Front 62

DOC Atypicals [Chlamydia, Mycoplasma] for a prenant woman?

Back 62

Macrolide

Front 63

DOC for Borrelia in Children?

Back 63

Amoxicillin

Front 64

DOC N. gonorrhea in Children?

Back 64

Ceftriaxone

Front 65

DOC Atypicals in Children?

Back 65

Macrolides

Front 66

What is the Serotonin Sx?

Back 66

Hyperthermia
Rigidity
Autonomic Instability
Myoclonus

Kind of like when having sex!!!

Front 67

What causes Serotonin Sx in w/ Meperidine?

Back 67

Combination w/ MAOIs, TCAs
but it is a metabolite called normeperidine that acts like SSRI

Front 68

How do protease inhibitors work?

Back 68

Inhibit Aspartate Protease

Front 69

Name two protein inhibitors?

Back 69

Indinavir
RitonAVIR

gp120
gp41

Front 70

What happens to Uric Acid at high does Aspirin?

Back 70

UA stays in the lumen and is peed out = uricosuric

Front 71

What happens to Uric acid w/ low dose Aspirin?

Back 71

Transport of UA (Uric Acid) is blocked from the blood to the lumen so it causes hyperuricemia
Aspirin (low dose) blocks secretion of Uric Acid

Front 72

What drug protects patient from nephrotoxicity taking cisplatin?

Back 72

Amifostine

Front 73

What drug prevents cardiotoxicity w/ Doxorubicin?

Back 73

Dexrazoxane

Front 74

What drug prevents toxicity to epithelial, GI and bone marrow in Methotrexate high dose anti-cancer tx?

Back 74

Leucovorin
restores purines

Front 75

Where does Aspirin work?

Back 75

COX-1
Cycloxygenase 1

Front 76

Where does abcximab work?

Back 76

GP IIB/IIIA receptor on platelets. Can't join together

Front 77

Where does ticlopidine work? (Clopidrogel)

Back 77

Blocks ADP release

Front 78

Where does propilthioracil and Methimazole work?

Back 78

Peroxidase in thyroid synthessis

Front 79

Where does Iodide (high dose) work?

Back 79

blocks release of proteolytic T3 ---> T4

Front 80

Where does Propilthioracil and Propanolol work?

Back 80

inhibit deiodinase (liver) conversion of T4 to T3