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16 Cards in this Set

  • Front
  • Back
Where SPECIFICALLY is ADH synthesized?
Cell bodies of neurons in the supraoptic and paraventricular nuclei of the hypothalamus.
From where is ADH stored and realeased from?
ADH is stored and released from the posterior pituitary.
What is the major target tissue and the action on the target tissue of ADH.
Renal Collecting Duct and the action is increased water reaborption.
What does ADH stimulate the reabsorption of?
what does it not stimulate the reabsorption of?
Stimulates the reabsorption of water and urea, but does not stimulate the reabsorption of electrolytes.
How is the reabsorption accomplished.
ADH increases the permeability of renal collecting ducts and thus water is reabsorbed PASSIVELY, and thus does not dramatically effect the oxygen consumption of the kidney.
Which stretch receptors are important and the regulation of release of ADH.
The stretch of the large venous vessels.
What is primary polydipsia?
This is the same as water intoxication. The person is taking in too much fluid. This brings the osmolarity down and thus decreases the secretion of ADH.
What happens in central (neurogenic) diabetes insipidus
You have an inability to secrete ADH. Remember that this is the neurogenic (central form), not the nephrogenic form.
What does SIADH stand for?
Syndrome of Inappropriate ADH Secretion (SIADH)
What is SIADH and what is it do to?
SIADH is a hypersecretion of ADH usually do a cancerous tumor.
What is Atrial Natriuretic Peptide (ANP)?
hormone secreted by the muscular tissue of the heart.
Where is the heart is ANP mainly found?
found throughout the heart but mainly in the reight atrium.
What is the stimulus to release ANP?
-stimulus to release ANP is stretch of the atrium.
-also secreted in response to increased salt intake
What is the target tissue and action of ANP?
ANP increases sodium loss (natriuresis) and water loss by the kidney
What is the mechanism of ANP action in the kidney?
the sodium and thus water loss due to ANP in the kidney is MAINLY due to an increase in glomerular filtration rate, but it also reduces the sodium and water reabsorption from the collecting ducts.
What is the increased glomerular filtration rate do to?
ANP mediated dilation of the afferent arteriole and
ANP medicated constriction of the efferent arteriol.