Jw Uhcl Developmental Biology Final Ch10

Front 1

TWO ROWS OF MATCHING
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Back 1

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Front 2

LIST STEPS/INFORMATION OF....
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Back 2

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Front 3

--- Neural Crest ---
1) Derived from *** germ layer...
2) in the *** region of *** *** structure
3) prospective *** *** and prospective *** also contribute .

Back 3

1) ectoderm
2) dorsal --- neural tube
3) neural plate --- epidermis

Front 4

--- Neural Crest ---
Divided into these *** main functional domains.......................

Back 4

four
#1 – Cranial N.C.
#2 - Cardiac N.C.
#3 - Trunk N.C.
#4 - Vagal and sacral N.C.

Front 5

*** are blocks of mesoderm surrounding neural tube
which differentiate into spine vertebral cartilage.

Back 5

Sclerotomes

Front 6

Vagal & Sacral NCC generate *** and *** ganglia of the gut.

Back 6

parasympatheric --- enteric

Front 7

--- VAGAL & SACRAL NCCs ---
1) Failure to migrate to colon results in missing *** ganglia
2) causing absence of *** movement and subsequently ***colon.

Back 7

1) enteric
2) peristaltic --- mega

Front 8

--- Neural Crest ---
1) Vagal NCCs are opposite to somites(#).
2) Sacral NCCs are posterior to somites(#).

Back 8

1) 1 - 7
2) 28+

Front 9

--- Neural Crest ---
1) *** NCCs develop into melanocytes.

Back 9

Trunk(main)
cardiac(minor)

Front 10

!!!--- Cardiac NCCs form ---
1) *** that separates *** circulation from the ***.
2) wall of large ***.

Back 10

1) septum --- pulmonary --- aorta
2) arteries

Front 11

!!! --- Cranial NCCs ---
1) form *** cells
2) *** and *** (tissues) of inner ear and jaw.
3) P*** and cranial nerves

Back 11

1) thymic
2) cartilage/bone
3) Pigment

Front 12

--- TRUNK NCCs ---
1) Have # pathways.
2) Melanocytes migrate ***.
3) Sympathetic Ganglia migrate *** through *** of sclerotome.

Back 12

1) 2
2) dorsolaterally
3) ventrolaterally --- anterior

Front 13

--- *** NCCs ---
Have 2 migration pathways, either *** or ***.

Back 13

TRUNK
Dorsolaterally --- ventrolaterally

Front 14

--- TRUNK NCCs ---
Two Migration Pathways
1) Dorsolateral migrants form ***.
2) Ventrolateral migrants go through *** of sclerotome forming *** ***.

Back 14

1) melanocytes
2) anterior --- sympathetic ganglia

Front 15

Sympathetic ganglia formed from *** migrating *** NCCs.

Back 15

Ventrolaterally --- Trunk

Front 16

Ventrolateral migration of Trunk NCCs form...
1) *** *** ganglia
2) *** ganglia
3) *** cells
4) *** cells

Back 16

1) dorsal root ganglia
2) sympathetic ganglia
3) adrenomedullary cells
4) schwann cells

Front 17

--- Autonomic Nervous System (ANS) ---
1) *** NERVOUS SYSTEM
2) *** NERVOUS SYSTEM
3) *** NERVOUS SYSTEM

Back 17

SEP
1) sympathetic
2) enteric
3) parasympathetic

Front 18

Trunk NCCs are transiently located above *** *** dispersing soon after its ***.

Back 18

neural tube
Closure

Front 19

!!! --- Neural Crest ---
Trunk Melanocyte NCCs - Path 1/2
1) ***(direction) migration through dermal *** underlying dermis.
2) Enter epidermis through minute holes in *** ***.
3) Colonize skin and hair ***.

Back 19

1) dorsolateral --- mesoderm
2) basal lamina
3) follicles

Front 20

*** NCCs form adrenomedullary and *** root schwann cells.

Back 20

Trunk --- ventral

Front 21

*** NCC followed w/radiolabeled neural tube graphs.

Back 21

Trunk

Front 22

Ventrolateral Trunk NCCs
1) Cells posterior to scleretome migrate ***
2) to enter anterior region of next ***.

Back 22

1) down
2) sclerotome

Front 23

1) Each *** *** *** is composed of three NCC populations from opposite somites.

Back 23

1) dorsal root ganglion

Front 24

Each dorsal root ganglion is composed of # *** NCC populations from opposite portion of ***.

Back 24

three trunk --- somites

Front 25

--- Premigratory NCC ---
Migration proteins Slug and RhoB are induced by *** and *** in presumptive ***.

Back 25

BMP4 and BMP7 --- epidermis

Front 26

--- Premigratory NCC ---
No migration occurs if *** OR ***(proteins) is missing.

Back 26

Slug --- RhoB

Front 27

--- Premigratory NCC ---
*** – p*** establishes cytoskeletal condition for migration.

Back 27

RhoB --- positively

Front 28

--- Premigratory NCC ---
*** – activates factors that dissociate tight junction.

Back 28

SlugB

Front 29

--- Premigratory NCC Factors---
1) *** - Protein related to tight junctions.
2) *** - Protein related to cytoskeleton.
3) ***-Regulation of *** expression linking NCC together.

Back 29

1) SlugB
2) RHOB
3) Down --- N-Cadherin

Front 30

--- Premigratory NCC ---
3rd factor involved
1) Down-regulation of *** expression linking NCC together.
2) After migration/during formation of *** it is reexpressed.

Back 30

1) N-Cadherin
2) ganglion

Front 31

--- Trunk NCC Migration ---
1) Controlled by ***(region) surrounding *** ***(structure).
2) # sets of proteins are involved
3) functioning as................ factors.
4) The *** set provides migration specificity.

Back 31

1) ECM --- Neural Tube
2) Two
3) Promoting and Impeding
4) Impeding

Front 32

--- Trunk NCC Migration ---
IMPEDING proteins
1)
2)

Back 32

Ephrin proteins
Eph receptor

Front 33

--- Trunk NCC Migration ---
PROMOTING proteins which originate from *** tissue include....
1) F***
2) L***
3) Tenascin
4) Various C***
5) Pr*** sulfates

Back 33

mesoderm
1) Fibronectin
2) Laminin
3) Tenascin
4) Collagen
5) Proleoglycan sulfates

Front 34

--- Trunk NCC Migration ---
1) Main IMPEDING protein is ***.
2) Expressed in *** side of *** cells
3) with its “*** receptor” on *** cells.

Back 34

1) ephrin
2) post --- sclerotome
3) eph --- NCC.

Front 35

--- Trunk NCC Migration ---
"Promoting/Impeding" proteins originate from mesoderm.

Back 35

Promoting

Front 36

--- Trunk NCC ---
1) Are ***, differentiateing into
2) many cell types depending on ***.
3) *** cartilage of the eye transplanted
4) to trunk region forming *** ganglion neurons,
5) a*** cells, and g*** s*** cells.

Back 36

1) pluripotent
2) location
3) Sclera
4) sensory
5) adrenomedullary --- glial schwann

Front 37

1) White of the eye is called ***.
2) Outer, fibrous, protective layer containing c*** and e*** fiber.

Back 37

1) Sclera
2) collagen --- elastic

Front 38

*** - Potential to differentiate into any germ layer.
***, ***, or ***.

Back 38

Pluripotency
Endoderm, Mesoderm, Ectoderm

Front 39

*** - Potential to differentiate into multiple but limited number of lineages.

Back 39

Multipotency

Front 40

--- NCC Potency ---
1) *** as they leave crest.
2) *** after migration begins; however, some
3) remain *** while others develop *** cell fates.

Back 40

1) pluripotent
2) Multipotent
3) pluripotent --- restricted

Front 41

--- NCC Potency ---
1) Cells migrating early are *** restricted.
2) Cells migrating late are *** restricted

Back 41

1) less
2) more

Front 42

1) Face is largely a product of *** NCCs.
2) Jaws, teeth and facial *** due to changes NCC placement.

Back 42

1) Cranial
2) cartilage

Front 43

Migrating NCCs form heart septum from Tr***s Arter***.

Back 43

Truncus Arteriosus

Front 44

--- Hindbrain Cranial NCCs ---
NCCs originating from *** 2/4/6 populate 1st/2nd/3rd 4th *** *** respectively.

Back 44

Rhombomere --- pharyngeal pouches

Front 45

--- Three *** Cranial NCC Pathways ---
Rhombomere # migrates to # Pharyngeal Pouch
1) # - #
2) # - #
3) # - #

Back 45

Hindbrain

1) 2- 1st
2) 4 - 2nd
3) 6 - 3rd/4th

Front 46

1) There are # Pathways for Hindbrain Cranial NCCs.
2) Each group migrates from a *** to a ***.

Back 46

1) 3
2) Rhombomere --- Pharyngeal Pouch

Front 47

--- Cranial NCCs ---
In mammals they migrate before neural tube *** forming f*** m***.

Back 47

Closure --- facial mesenchyme

Front 48

Rhombomere 6(3rd & 4th P.P.) forms
1) T***
2) P*** g***
3) T*** g***
4) v*** g***
5) g*** n***

Back 48

1) Thymus
2) Parathyroid gland
3) Thyroid gland
4) vagus ganglia
5) glossopharngeal nerve

Front 49

Rhombomere 4(2nd P.P.) forms
1) H*** c***
2) Other g***

Back 49

1) Hyoid cartilage
2) Other ganglions

Front 50

Rhombomere 2(1st P.P.) forms
1) Ganglion of *** ***
2) F*** n*** p***

Back 50

1) trigeminal nerve
2) Fronto nasal processes

Front 51

Anterior Hindbrain NCCs form Mesenchyme of *** Pharyngeal ***.
Forebrain and Midbrain NCCs form Mesenchyme of *** Pharyngeal ***.

Back 51

2nd --- Arch
1st --- Pouch

Front 52

Forebrain and Midbrain NCCs form....
1) N*** p***
2) P***
3) *** of # Pharyngeal Pouch (gills/jaw)

Back 52

1) Nasal process
2) Palate
3) Mesenchyme --- 1st

Front 53

*** and *** Cranial NCCs form...
Nasal process, Palate, Gills, Jawbone, Earbones

Back 53

Forebrain and Midbrain

Front 54

1) Not all *** NCCs are multipotent. However, if it produces
2) cartilage it will continue producing cartilage even if ***........

Back 54

1) Cranial
2) transplated into different region

Front 55

In some cases, *** NCCs differentiate at an early stage.

Back 55

Cranial

Front 56

*** NCCs have only recently been appreciated.

Back 56

Cardiac

Front 57

Cardiac N.C. makes up the *** region of the *** NCCs.

Back 57

caudal --- cephalic

Front 58

Caudal region of cephalic NCCs is made of *** N.C.

Back 58

Cardiac

Front 59

*** is the thin layer lining interior of blood vessels.

Back 59

Endothelium

Front 60

!!! Only Cardiac NCCs can form
1) *** of *** *** arteries
2) *** between aorta and *** artery.

Back 60

Endothelium --- aortic arch
Septum --- pulmonary

Front 61

Replacement of Cardiac NCC causes failure of ***-*** ***.

Back 61

aortic-pulmonary separation

Front 62

Congenital heart defects often occur in ***, ***, and ***.

Back 62

parathyroid
thyroid
thymus glands

Front 63

Draw diagram of the 3 developing germ layers.
How many?

Back 63

9