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12 Cards in this Set
- Front
- Back
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What enzymes help convert protoporphyrin to heme?
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ferorchetalase
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Once Hemoglobin is catabolized, what happen to its products?
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Globin is recycled or catabolized into AA's
Heme is broken into Fe which is recycled and biliverdin |
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What enzymes helps break down heme to biliverdin?
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heme oxygenase
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What enzyme converts biliverdin into bilirubin?
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biliverdin reductase
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Once bilirubin is taken into hepatic cells via transporters, what is it conjugated with?
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bilirubindiglucuronide
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What enzymes help conjugate this?
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UDP glucuronyl transferase
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What are the main causes of jaundice (hyperbilirubinemia)?
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1) increase production
2) decreased clearance 3) Increased reuptake into intestine |
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What are some pathologies that cause increase RBC's (polycythemia) in newborns?
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Twin circulations problems and also maternal-baby circulation, diabetic mothers
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Same question but for increased turnover?
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cephalohematomas, hemolysis pathologies such as HS, G6PD deficiency, ABO and Rh incompatibilites
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Same question but for decreased conjugation?
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competitive inhibition of glucorynl transferase in breast milk, Gilbert's syndrome, Crigler-najir syndrome
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Decreased excretion examples?
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conjugated hyperbilirubinemia:
hepatocellular path's Biliary tree abnormalities |
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Increased reabsorption (uncogugated bilirubin)
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distal obstruction of any kind,
poor feeding causing poor motility |
