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15 Cards in this Set
- Front
- Back
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Physiologic jaundice
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2nd-3rd day after birth
Immaturity of conjugating enzymes (deficiency in glucuronyl transferase) Self resolves, phototherapy |
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Biliary atresia
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After 2 week of birth
Increased conjugated bilirubin in neonates Obstructive signs-dark urine and clay-colored stools Dx: US Tx: surgery to pretent biliary cirrhosis |
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Kernicterus
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Irreversible, fatal unconjugated bilirbin that gets deposited in basal ganglia.
Hypertonia, seizures, poor feeding, high-pitched cry |
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ABO incompatibility
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Hemolysis which increases indirect bilirubin and jaundice
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Hypothyroidism
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Jaundice, hypotonia, protruding tongue, lethargy, delayed closure of fontanelles
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Hypercarotenemia
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Jaundice with no scleral icterus
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Exaggerated physiologic jaundice
aka breast feeding jaundice |
First week of life
tx: feed baby more than 10 feeds/day |
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Breast milk jaundice
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Start 4-14 days (after 1st week) secondary to substances in breast milk.
Tx/Dx: improvement with formula in 48-72 hours. |
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RH incompatability
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Erythroblastosis fetalis
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Other
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Trauma, cephaolhematoma, bruising, infection, polycthemia
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Congenital hemolytic anemia
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spherocytosis, glucose-6-phosphate deficiency, pyruvate kinase deficiency
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Gilbert's
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Mild defect of glucuronyl transferase
Increased unconjugated bilirubin |
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Crigler-Najjar
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Deficiency of glucuronyl tranferase causing increase serum unconjugated bilirubin
Tx: phenobarbital |
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Dubin-Johnson
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Increased conjugated bilirubin due to defective bilirubin excretion
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Rotor
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Increased conjugated bilirubin
Defect is in bilirubin storage, not excretion (like Dubin-Johnson) |
