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13 Cards in this Set
- Front
- Back
Aspirin
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75-325mg daily
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Clopidogrel dose
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Plavix 300-600mg LD
75mg combo with ASA 1 month BMS 3 months sirolimus stent 6 months paclitaxel stent |
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Glycoprotein IIb/IIIa meds?
MOA: blocks GP receptor in the final pathway of platlet aggregation |
EAT / IRA
Eptifibatide - Integrilin * Abciximab- Reopro Tirofiban (Aggrastat)* *renal dose adjust and indicated for adjunct PCI and medication management tx |
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LMWH
Enoxaprin |
Lovenox
1mg/kg SC q12 CrCl <30 once daily dosing Can give IV loading dose |
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LMWH
Dalteparin |
Fragmin
120IU/kg q12 max 10,000IU q 12 renal dose adjust |
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Heparin
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enhances action of antithrombin III
LD 60-80U/kg, MD 12-15U/kg/hr apTT 1.5-2x control for 48hrs |
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Protamine
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antidote for heparin
1mg per 100U of heparin |
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Abciximab
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Reopro (antibody)*allergic rxn
Not renally adjusted Not for solo tx must be given with planned PCI |
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Eptifibatide
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Integralin (nonpeptide)
renal dose adjust C/I SCr>4 or dialysis |
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Tirofiban
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Aggrastat (peptide)
renal dose adjust |
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thienopyridines
Clopidogrel Ticlopidine blocks adenosine diphosphate mediated activation of platelets |
300-600mg LD then 75mg QD
500mg LD then 250mg QD Ticlopidine needs monitoring of CBC, LFTs DC if WBC drop below 1200 or plts below 80k neutropenia and thrombocytopenia |
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Aspirin blocks prostaglandin synthesis prevents formation of thromboxane A2
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onset of chest pain chew 160-325mg then MD 75-325mg for life
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TX choice for Prinzmetal's
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Angiospasms
CCB or nitrates no BB |