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8 Cards in this Set
- Front
- Back
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What is the "double product"?"
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HR * systolic pressure
clinical index of myocardial oxygen demand |
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mechanism of nitrates (nitroglycerin)
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at cellular level, increase NO which stimulates cGMP formation
at hemodynamic level, induces venodilatation -> decrease venous return -> decrease filling pressure -> decrease wall tension -> decrease O2 consumption |
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beta blockers are effective in the prophylatic treatment of...
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stable angina because they reduce oxygen demand by decreasing HR and contractility
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beta blockers are contraindictaed in
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variant angina
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beta blockers vs nitroglycerin
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beta blockers have longer duration than nitroglycerin, and less problem with tolerance
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verapamil
diltiazem nifedipine |
first generation Ca2+ channel blockers
phenylalkalamine benzothiazepinone 1,4 dihydropyridine |
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difference between nifedipine and diltiazem/verapamil
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nifedipine has less depressant activity on heart.. may cause baroreflex tachycardia
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treatment of exertional angina vs variant angina
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exertional can be treated with beta blocker... beta blocker is contraindicated in variant angina -> can use Ca2+ channel blocker, aspirin and heparin
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