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13 Cards in this Set
- Front
- Back
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Rifampin Method of Action |
Inhibits RNA Synthesis Binds to RNA Polymerase |
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Binding to RNA polymeras causes |
Inhibition of enzyme binding to DNA Inhibition of RNA transcription |
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Rifampin (Generic) |
Rifadin (brand) |
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Why is Rifampin safe for treatment |
Does not bind in eukaryote cells |
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Dosage forms of Rifampin |
Capsule and injection |
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Dosage in TB |
10mg/kg/day MAX 600 mg/day |
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Dosage in meningitis |
1200mg/day |
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Side effects of Rifampin |
Red/Orange urine Hepatitis Flushing/Rash/Itching Renal Issues Flu-like Psuedomonas Colitis |
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Organisms range of Rifampin |
Mycobacterium (m. Leprosy- Hansen's) (m. Avium) (m. Turbuculosis) Neiseria Meningitis (asymptomatic) Staph Aureus (MSSA MRSA Epididermis) H.Influenzae Legionella |
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Contraindications of Rifampin |
Protease inhibitors |
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Labs to monitor on Rifampin |
CBC LFT Platelet count Serum Creatine |
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What is the Hepatic dose |
Less than or equal to 8mg/kg/day (PO & IV) |
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Pathways affected by Rifampin |
1A2, 2B6, 2C19, 2C9, 3A4 p-glycoprotiens UGT1A |
