Ipapburke Pharm2 Test 1- Fq

Front 1

What is the spectrum of coverage for FQ?

Back 1

wide variety of gram negative organisms and some gram positive organisms

Front 2

What is the black box warning on Trovafloxacin?

Back 2

serious liver injury---> leading to liver transplantation and death

Front 3

What is the MOA of FQ?

Back 3

inhibits the replication of bacterial DNA by interfering with DNA gyrase (bacterial topoisomerase II)

Front 4

What is DNA gyrase or bacterial topoisomerase II needed for?

Back 4

bacteria to replicate, transcribe, and repair DNA

Front 5

What is the antipseudomonal FQ?

Back 5

Ciprofloxacin

Front 6

Uses for FQ

Back 6

UTIs, prostatitis, gonorrhea, infectious diarrhea, CAP

Front 7

What are FQ used for as alternate medications?

Back 7

bronchitis, sinusitis, skin

Front 8

What are the FQ on the BCF?

Back 8

Ciprofloxacin, Levofloxacin, and Gatifloxacin

Front 9

What is the broadest spectrum FQ?

Back 9

Trovafloxacin

Front 10

MC Side effects in FQ

Back 10

GI side effects and CNS side effects

Front 11

GI side effects of FQ

Back 11

diarrhea, nausea, and vomiting

Front 12

CNS side effects of FQ

Back 12

HA, dizziness, agitation, and rarely sleep disturbances; use w/ caution in epilepsy

Front 13

What is the side effect of FQ that essentially makes them a contraindication in children?

Back 13

tendonitis and achilles tendon rupture

Front 14

What is the side effect when using Sparfloxacin and Moxifloxacin?

Back 14

increased QT interval

Front 15

What FQ has caused nephrotoxicity due to crystalluria?

Back 15

Cipro

Front 16

What FQ causes acute hepatitis and hepatic failure?

Back 16

Trovafloxacin

Front 17

Contraindications for FQ

Back 17

avoid in pregos and kids under 18 due to articular cartilage erosion

Front 18

Pathogen in 90% of first time UTIs

Back 18

E Coli

Front 19

What drug is used for prophylaxis for UTI?

Back 19

1 RS Septra daily or 2 DS one time at symptom onset or 1 DS tab post-coitus

Front 20

If there is less than 20% resistance to sulfa in UTI, what drug is used?

Back 20

Sulfa for 3 days

Front 21

If there is more than 20% resistance to sulfa, what drug should be used for UTI?

Back 21

use NF for 7 days or FQ (Cipro)for 3 days

Front 22

How long is drug therapy for UTI in pregnancy?

Back 22

7 days

Front 23

What groups are more likely to get UTIs?

Back 23

women of child bearing age, elderly, spinal cord injuries

Front 24

Drug good for complicated UTI

Back 24

Gentamicin

Front 25

What is the MOA for Nitrofurantoin?

Back 25

inhibits bacterial enzymes and damages bacterial DNA

Front 26

What is the spectrum covered by Nitrofurantoin?

Back 26

both gram negative and positive including E. coli

Front 27

What color will Nitrofurantoin turn urine?

Back 27

brown

Front 28

What increases the bioavailability of Nitrofurantoin ?

Back 28

food

Front 29

What are the GI side effects of Nitrofurantoin?

Back 29

N/V, diarrhea---reduce by taking with food

Front 30

What is acute pneumonitis?

Back 30

pulmonary sensitivity reaction to NF- rare

Front 31

What patient population is NF C.I. due to hemolytic anemia side effect?

Back 31

in patients with G6PD deficiency

Front 32

How do many providers use NF in regards to UTIs in pregnancy women?

Back 32

some use first line even with risks

Front 33

This drug exerts a local anesthetic or analgesic action on urinary tract mucosa

Back 33

Pyridium (Phenazopyridine)

Front 34

What drugs turns urine orange or red and can stain clothing?

Back 34

Pyridium (Phenazopyridine)

Front 35

What is the spectrum of coverage for Flagyl?

Back 35

anaerobic bacteria and protozoa

Front 36

MOA for Flagyl

Back 36

causes cell death by forming cytotoxic compounds that bind to proteins and DNA

Front 37

Specific NF agents

Back 37

Nitrofurantoin (Macrodantin and Macrobid)

Front 38

Pyridium must be used in conjunction with what?

Back 38

an antibacterial agent

Front 39

Indications for Flagyl

Back 39

anaerobic intraabdominal infections including antibiotic associated enterocolitis C. Dificile, bacterial vaginosis, H. pylori, and amebiasis

Front 40

Adverse reactions to Flagyl (Metronidazole)

Back 40

N/V, cramps

Front 41

Why should alcohol be avoided during therapy with Flagyl?

Back 41

due to disulfuram reaction

Front 42

What protozoal infections does Flagyl cover?

Back 42

E. histolytica, Giardia, and Trichomonas

Front 43

What is the use for Mupirocin (Bactroban cream/ointment)?

Back 43

inhibits and kills S/ aureus including MRSA-- use in impetigo and MRSA nasal carriers

Front 44

What is the use for Polymyxin B?

Back 44

used against gram negative bacteria and usually mixed with bacitracin or neomycin in several OTC agents