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27 Cards in this Set

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MOA of Cephalosporins
cell wall inhibitors
Spectrum of 1st generation Cephalosporins
similar to Pen G; they are resistant to penicillinases/ B lactamases (Staph and Strep
Spectrum of 2nd generation Cephalosporins
weaker gram positive, but some gram negative and anaerobic activity (similar to B lactamase inhibitors)
Spectrum of 3rd generation Cephalosporins
enhanced gram negative activity, but inferior ti first generation agents against gram positive
Spectrum of 4th generation Cephalosporins
wide spectrum
How do cephalosporins cause superinfections?
can kill normal flora of the gut
Overall side effect profile of cephalosporins
generally well tolerated and have few major side effects
Oral First Generation Cephalosporins
Cephradine (Velosef), Cefadroxil (Duricef) and Cephalexin (Keflex)
What are the injectable First generation Cephalosporins?
Cefazolin (ancef and Kefzol)
Spectrum of First Gen Cephalosporins
like Pen G with resistance to penicillase
For what do you use oral first generation Cephalosporins (Velosef, Duricef, Keflex)?
skin/ skin structure infections (Staph aureus and Group A strep) and UTIs
UTI
1st gen Cephalosporins (Velosef, Duricef, Keflex)
pre/post surgery involving abdomen
Ancef and Kefzol
What are the second generation Cephalosporin oral agents?
Cefaclor (Ceclor), Cefprozil (Cefzil), and Cefuroxime (Ceftin)
What are oral second generation Cephalosporins used for?
resistant otitis media, alternate for CAP, pharyngitis, and cat bites
What are the injectable Second generation Cephalosporins?
Cefuroxime (Zinacef) and Cefoxitin (Mefoxin)
What is Cefoxitin (Mefoxin used for?
used in pre and post surgery cases involving the abdomen
What is the injectable 3rd generation Cephalosporin?
Ceftriazone (Rocephin)
What STD is Rocephin used to treat?
N. gonorrhea urethritis
If using Rocephin Im, what can it be mixed with?
lidocaine
Rocephin can be used for these conditions
resistant OM, meningitis, pharyngitis (gonococcal)
What is the antipseudomonal cephalosporin?
Ceftazidime (Fortaz)
What are the third generation IV cephalosporins?
Cefotaxime (Claforan) and Ceftazidime (Fortaz)
What are the third generation IV cephalosporins used for?
severe gram negative infections including meningitis, endocarditis, joint infections, and multiple other infections
What is the fourth generation Cephalosporin?
Cefepime (MAxipime)
What is use for Cefepime?
used as a empiric therapy in febrile neutropenia
Mazimpime can also be used against what 3rd generation resistant strains such as (2)
Enterobacter and citrobacter