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25 Cards in this Set
- Front
- Back
MOA for tetracylcines
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inhibit bacterial protein synthesis at the 30S subunit of the bacterial ribosome
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Is tetracycline broad or narrow spectrum?
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broad spectrum
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Why is tetracycline not used for serious hospitalized infections?
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because it is bacteriostatic- slowly kills the bacteria
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What is the widespread resistance to tetracylcines related to?
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the organisms inability to accumulate the drug (efflux pump)
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Normal use for tetracycline
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acne
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How is the oral absorption of tetracyclines reduced?
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by food, divalent cations (Ca, Mg, Fe), dairy products, and antacids
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What are the exceptions to oral absorption of tetracyclines being reduced by food?
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Doxycycline and Minocycline
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What tetracyclines are eliminated renally?
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Tetracycline and minocycline
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What tetracycline is eliminated in the feces?
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Doxycycline
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Which tetracycline can be used in renal failure patients?
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Doxycycline
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GI adverse effects of Tetracycline
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N/V and diarrhea
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How do you reduce the GI side effects of tetracycline use?
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reduced by taking the med with food, but absorption will be reduced, o tell patients to avoid daily produces/antacids 1 hour before and 2 hours after using
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Deposition in calcified tissues causes what side effect that makes using Tetracyclines contraindicated in kids
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gray teeth
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Why is there phototoxicity with tetracyclines?
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very wide volume distribution so there is possibility of a UV induced rash
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Why are the contraindications to tetracyclines?
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renal impairment (except Doxy), pregnant or breast feeding, children under 8
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What form is Tetracycline (Sumycin)?
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oral
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What are the 2 uses for Tetracycline (Sumycin)?
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acne vulgaris and Helicobacter pylori
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What are the two forms of Doxycycline?
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oral and injection
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DOC for CAP
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Doxycycline (Vibramycin)
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What STD is Doxy an alternate treatment for?
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Chlamydia
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What Rickettsiae species is Doxy used for?
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Rocky Mountain Spotted Fever
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What spirochete is Doxy used against? What disease does it cause?
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Borrelia burgdorferi- Lyme Disease
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Use for Minocycline (Minocin)
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alternate for acne treatment
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Side effects of Minocycline (Minocin)
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dizziness, nausea, vomiting due to concentration in the ear
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What is the only tetracycline with outpatient MRSA coverage?
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Minocycline (Minocin)
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