Ipapburke Inf Dz Test 3- Rick Dz

Front 1

Describe Rickettsiae organism.

Back 1

obligate intracellular gram negative coccobacilli that does not stain well with Gram stain

Front 2

Natural host for Rickettsiae organism

Back 2

mammals and arthropods

Front 3

Usual transmission of Rickettsiae organism

Back 3

from arthropods to humans (exception- Q fever)

Front 4

3 groups of Rickettsial disease

Back 4

Spotted Fever group, Typhus Group, and other

Front 5

Pathophysiology of Rickettsial Disease

Back 5

multiply within endothelial cells--> enter bloodstream--> invade the cells near the vascular causing fluid to leak out into tissue space--> affects all organs. but esp. the skin and adrenals and secondarily the CNS, heart, and live

Front 6

Where are Rickettsial organisms most often found in body?

Back 6

skin and adrenals

Front 7

Common treatments for Rickettsial diseases

Back 7

Doxycycline (CI under 8) and Chloramphenicol

Front 8

Commonalities between Rickettsial diseases

Back 8

Tx, pathophysiology, zoonotic trait, rash, and diagnosis by serology or PCR

Front 9

Mortality is uncommon under 12 y/o with this condition

Back 9

Louse Borne Typhus

Front 10

Mortality rate with untreated RSMF

Back 10

25%

Front 11

Most deadly Rickettsial Disease

Back 11

Louse Borne Typhus (60-70% in people over 50)

Front 12

What will be the nonspecific lab findings in Rick. disease?

Back 12

leukopenia, hyponatremia, and thrombocytopenia

Front 13

What is the confirmation test for diagnosis of Rick. disease?

Back 13

serology (there is cross sensitivity between Rick. diseases)

Front 14

Why is culture not done in Rick. diseases?

Back 14

it is difficult and dangerous

Front 15

Organism in Louse Borne Typhus

Back 15

Rickettsia prowazeki

Front 16

Vector for Louse Born Typhus

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live- Pediculus humanus

Front 17

Where have most of the cases of Louse Borne Typhus been in the last 2 decades?

Back 17

Africa- esp. Ethiopia and Nigeria (also other OVERCROWDED areas in Europe and Asia)

Front 18

S/S of Louse Borne Typhus

Back 18

abrupt onset 1-2 wks after exposure--> fever, intractable HA, rash day 4-7 that moves from trunk to extremities, spares face/palms/soles, progresses from macules to maculopapules to petechiae

Front 19

Possible complications of Louse Borne Typhus

Back 19

gangrene, pericarditis, myocarditis, pleural effusion, pneumonia, and in severe cases--. meningoencephalitis, delirium, and fatal cardiac or renal failure

Front 20

Name for relapsing louse borne typhus usually 10-20 years later

Back 20

Brill Zinsser Disease

Front 21

S/S of Brill-Zinsser Dz

Back 21

usually more mild and less debilitating--> fever, transient rash, falling BP

Front 22

Where does the typhus organism linger in latent state?

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spinal marrow

Front 23

Test taking- Key Words

Back 23

lice, overcrowding, trunk to extremity progression, intractable HA, not on face/palms/soles

Front 24

Another name for Murine Typhus

Back 24

endemic or flea borne typhus

Front 25

Organism in Murine typhus

Back 25

Rickettsia typhi

Front 26

How is Murine transmitted?

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from rat to rat by a rat flea and then accidentally to humans by flea feces

Front 27

Where is Murine typhus most prevalent?

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in large cities in coastal regions--Texas and California

Front 28

S/S of murine typhus

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less severe than louse borne--milder fever, shorter course, less severe HA, less extensive rash that is only found in 50%

Front 29

Vector and organism for RMSF

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Rickettsia rickettsia; wood ticks and dog ticks

Front 30

What area of US have RMSF?

Back 30

all--> but endemic to South Atlantis, Midwest, West south central

Front 31

When is there mortality with RMSF?

Back 31

when diagnosis and treatment is delayed

Front 32

S/S of RMSF

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GI symptoms in early stages, skin necrosis, cardiac involvement, atelectasis, retinal disease,, enlargement of liver or spleen

Front 33

What are the cardiac manifestations of RMSF?

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arrhythmias and congestive heart failure

Front 34

What are the retinal disease manifestations of RMSF?

Back 34

papilledema and retinal artery occlusion

Front 35

Cardinal signs of RMSF

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fever of 104-105 that is persistent, persistent and retractable HA, rash on palms and soles initially that spreads, confusion, and myalgias that cause calf or thigh tenderness

Front 36

Test taking- Key words

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HSM, high fever, palms and soles, calf/thigh tenderness, retinal artery

Front 37

Organism in Q Fever

Back 37

Coxiella burnetii

Front 38

How does Q Fever organism cause disease?

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DIRECTLY affects various organs

Front 39

Lung involvement

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macrophages

Front 40

Heart involvement

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valvular vegetations

Front 41

Granulomatous changes in what organs?

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reticuloendothelial organs

Front 42

Where is Q fever common?

Back 42

in slaughterhouses, research facilities, and livestock handling plants

Front 43

Onset of Q Fever- abrupt or insidious

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abrupt

Front 44

S/S in Q Fever

Back 44

fever, intractable HA, chills, myalgia, cough, chest pain, pneumonitis, rash is absent, HSM

Front 45

What will be seen on radiographs of Q Fever?

Back 45

multiple segment opacities, pleural effusion, lobar consolidation, linear atelectasis