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42 Cards in this Set
- Front
- Back
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e. coli that is closely related to shigella sonnei (no toxin)
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enteroinvasive e. coli
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hemorrhagic colitis (bloody stool; cranberry sauce-like)
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enterohemorrhagic e. coli
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transmission of enterohemorrhagic e. coli
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foods, petting zoos, dairy farms
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sequelae of shiga-like toxin
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hemolytic uremic syndrome
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pathogenesis of enterohemorrhagic e. coli
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shiga-like toxin
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MOA of shiga toxin
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inactivates 60S ribosome to inhibit protein synthesis
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leading cause of acute renal failure in children
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diarrhea associated HUS (hemolytic uremic syndrome)
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hemolytic uremic syndrome pathogenesis
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inflammatory damage to glomerular endothelial cells
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clinical sx of HUS
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microangiopathic hemolytic anemia
thrombotic thrombocytopenic purpura acute renal failure |
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HUS occurs in what population
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children
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most common cause of HUS
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shiga like toxin from EHEC (0157:H7)
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can cause liver spleen abscesses and inflammatory colitis
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yersini enterocolitica
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common cause is non-pasteurization of dairy products
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yersini enterocolitica
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e. coli classification
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gram (-) rods
facultative anaerobes lactose fermenters |
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why does HUS cause TTP
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platelet consumption from thrombi in renal microvasculature
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classification of yersini enterocolitica
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non-motile/non-H2S
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classification of salmonella
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gram (-)
faculatative anaerobe non-lactose fermenters motile/H2S |
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classification of shigella
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gram (-)
faculatative anaerobe non-lactose fermenters non-motile/non-H2S |
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motility of vibrio and classification
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polar flagella
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classification of vibrio and campylobacter
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gram (-)
facultative anaerobe |
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leading cause of human gastroenteritis assx with seafood consumption
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vibrio paraheamolyticus
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population at high risk for vibrio parahaemolyticus infection
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japanese
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two toxins of vibrio parahaemolyticus
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thermostable direct hemolysis (TDH)
TDH-related hemolysin (TRH) |
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MOA of TDH/TRH (vibrio parahaemolyticus)
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forms pore in erythrocyte membrane causing lysis
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vibrio-like organism that is one of most common bacterial causes of acute diarrhea
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campylobacter jejuni
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the most common cause of inflammatory enteritis in US
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viruses
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curved gram (-) bacilli with polar flagella
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campylobacter
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gull-winged organisms with darting motility
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campylobacter
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campylobacter infection usually lasts how long
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5-8 days
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classification of clostridium difficile
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gram (+)
spore forming anaerobe motile |
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classification of bacillus cereus
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gram (+)
spore forming aerobe motile |
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lab dx of pseudomembranous colitis
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presence of toxin in stool by latex agglutination/EIA
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classification of clostridium difficile
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gram (+) bacillus
obligate anaerobes spore forming |
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leading cause of hospital-assx diarrhea
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clostridium difficile
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clostridium difficile toxins
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toxin A
toxin B |
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MOA of toxin A of clostridium difficile
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-opens tight junctions for toxin B to enter
-cytotoxic -ENS effects (substance P release) |
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MOA of toxin B of clostridium difficile
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-cytotoxic
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C. difficile toxin A effects on ENS
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increases substance P release, which causes mast cell degranulation causing Cl- secretion
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difference between cholera toxin and c. difficile toxin
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CT: fluid secretion w/o inflammation
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reactive polyarthritis
painful urination |
yersini enterocolitica
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guillen barre syndrome can be caused by what infection
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campylobacter
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causes pseudomembranous colitis
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clostridium difficile
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